n=35
2.2.1. demographic.
Data questionnaire was designed to assess the socioeconomic and lifestyle characteristics including smoking history, living situation, marital status, and medical history.
Body composition analysis was obtained via bioelectrical impedance analysis with a commercially available body analyzer (TANITA, USA). The subjects were asked to wipe the soles of their feet with a wet tissue and then to stand on the electrodes of the machine. Data was then recorded.
Cognitive function was evaluated using the MMSE and CANTAB tests. The MMSE is one of the most widely used tools for quantitative assessment of cognitive function. The test consists of 11 questions assessing various cognitive functions, including 2 questions on orientation, 1 on registration, 1 on memory, 5 on language, 1 on attention and calculation, and 1 on visual construction. The test has a maximum score of 30, with scores below 23 being indicative of cognitive impairment.
The delayed matching to sample simultaneously assesses visual matching ability and short-term visual recognition memory of patterns. The participant was shown a complex, abstract, visual pattern followed by four similar patterns after a brief delay. The participant selected the pattern that exactly matched the original pattern.
The AST tests the participant's ability to switch attention between the location of the arrow on the screen and its direction. This test was designed to measure top-down cognitive control processes involving the prefrontal cortex. The test shows an arrow that can point to either the right or left side of the screen and may appear on either the right or left side of the screen. Some trials displayed congruent stimuli (e.g., an arrow on the left side of the screen pointing to the left), whereas other trials displayed incongruent stimuli that required a greater cognitive demand (e.g., an arrow on the left side of the screen pointing to the right). The detail description of the task can be assessed from the website ( www.cantab.org ).
The intra-extra dimensional set shift is a test of rule acquisition and reversal. It features visual discrimination and attentional set formation maintenance, shifting, and flexibility of attention. This test is sensitive to changes in the frontostriatal areas of the brain and is a computerized analog of the Wisconsin Card Sorting Test. Two artificial dimensions were used in the test: the detail description of the task can be assessed from the website ( www.cantab.org ).
Participants reported their fast food consumption in the month before the survey. They were asked, “In the past month, how many times did you buy food at a restaurant where food is ordered at a counter or at a drive-through window?” They could respond using 1 of 9 frequency categories: never or rarely; 1 time per month; 2–3 times per month; 1–2 times per week; 3–4 times per week; 5–6 times per week; 1 time per day; 2 times per day; or 3 or more times per day. They were also given a list of the most popular fast food restaurants and were asked if they had gone to any of these restaurants in the past month.
Venous blood samples were collected from all participants after an overnight fast and analyzed for fasting blood glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) by using the enzymatic calorimetric method.
Quality of life was measured by the Ferrans and Power Quality of Life Index, which measures the quality of life in terms of satisfaction with life. The quality of life index are used to weight satisfaction responses so that the scores reflect satisfaction with the aspects of life that is valued by the individual. The quality of life index produces five scores (health and functioning, psychological/spiritual, social and economic, and family domains).
We calculated response time (ms), and numbers of percent correct trail in AST measurement. We measured DMS percent correct response, percent correct simultaneous, IED total error and IED stages completed between two groups. Independent samples t-tests were used for continuous variables, and the χ 2 test was used for categorical variables. All the statistical analyses were performed using 21.0 software (formerly SPSS Statistics Inc.). P < 0.05 was considered to be statistically significant. All data are expressed as means ±standard deviation (SD).
Group 1 included 35 participants with a mean age of 21.23 years, and group 2 included 25 participants with a mean age of 21 years. The demographic data are summarized in Table 1 .
The Fast Food Consumption (FFC) was determined by responding to the question, “How often (times/week) did you eat a meal or snack in Western-style FF restaurants (e.g., McDonald's, KFC, Pizza Hut) in the past one month?” Each FFC pattern was categorized as yes/no, and times of FFC per week (0, 1–2, and ≥3 times). Nearly 58% of the participants consumed less than 3 regular fast food meals per week, and 42% consumed 3 or more meals of fast food per week. Men consumed regular soft drinks more frequently than did women. All of the subjects were high school graduates which is expected in this age group especially in an urban city like Riyadh. Individuals who did not consume regular fast food smoked less, had a smaller waist circumference and a lower body mass index (BMI), and had a lower TG and higher HDL-cholesterol levels compared with those who consumed regular fast food daily.
3.2.1. cantab.
On the CANTAB test, There was not significant difference was found in the between two groups for AST congruency mean correct (Group 1 = 47.03 ± 57.34, Group 2 = 55.41 ± 41.17, t = −.625, P = 0.535, Table 2 ), AST Switching cost (Mean, correct) (Group 1 = 192.5 ± 133.8, Group 2 = 198.0 ± 140.6, t = −.156 P = 0.878, Table 2 ), AST Mean correct latency (Group 1 = 529.1 ± 101.4, Group 2 557.4 ± 113.2, t = −1.016, P = 0.314, Fig. 1 ; Table 2 ), AST mean correct latency (congruent) (Group 1 = 507.3 ± 101.2, Group 2 = 531.4 ± 109.4, t = −.876 P = 0.384, Fig. 1 ; Table 2 ), AST mean correct latency (incongruent) (Group 1 = 554.1 ± 109.6, Group 2 = 586.7 ± 120.2, t = −1.091 P = 0.280, Fig. 1 ; Table 2 ), AST mean correct latency (blocks 3,5) [non-switching blocks] (Group 1 = 437.7 ± 71.7, Group 2 = 462.0 ± 68.2, t = −1.322 P = 0.191, Table 2 ), AST mean correct latency (block 7) [switching block] (Group 1 = 624.9 ± 162.6, Group 2 = 660.1 ± 178.1, t = −.795 P = 0.430, Table 2 ) and AST percent correct trial (Group 1 = 92.7 ± 7.4, Group 2 = 92.4 ± 7.1, t = .191 P = 0.849, Table 2 ).
Cambridge Neuropsychological Test Automated Battery (CANTAB) data for two groups.
Group 1 n= 35 | Group 2 n= 25 | value | |
---|---|---|---|
Mean ± SD | Mean ± SD | ||
AST Congruency cost | 47.03 ± 57.34 | 55.41 ± 41.17 | 0.535 |
AST Switching cost | 192.5 ± 133.8 | 198.0 ± 140.6 | 0.877 |
AST correct latency | 529.1 ± 101.4 | 557.4 ± 113.2 | 0.314 |
AST correct latency (congruent) | 507.3 ± 101.2 | 531.4 ± 109.4 | 0.389 |
AST correct latency (incongruent) | 554.1 ± 109.6 | 586.7 ± 120.2 | 0.280 |
AST correct latency (blocks 3,5) [non-switching blocks] | 437.7 ± 71.7 | 462.0 ± 68.2 | 0.191 |
AST correct latency (block 7) [switching block] | 624.9 ± 162.6 | 660.1 ± 178.1 | 0.430 |
AST Percent correct trials | 92.76 ± 7.44 | 92.40 ± 7.17 | 0.849 |
DMS Percent correct | 90.42 ± 7.51 | 89.30 ± 5.70 | 0.530 |
DMS Percent correct (simultaneous) | 96.57 ± 4.81 | 98.40 ± 3.74 | 0.118 |
DMS Percent correct (all delays) | 88.38 ± 9.19 | 86.26 ± 7.14 | 0.346 |
IED Total errors (adjusted) | 18.48 ± 15.88 | 17.92 ± 17.68 | 0.897 |
IED Stages completed | 8.77 ± 0.64 | 8.68 ± 0.74 | 0.615 |
CANTAB test: CANTAB: Cambridge neuropsychological test automated battery, AST: Attention Switching Task, DMS: Delayed Matching to Sample, IED: Intra-Extra Dimensional Set Shift for two groups.
Mean response time (ms) for attention switching task correct latency, congruent and incongruent condition for two groups.
There was no significant difference for DMS percent correct response (t = .632, p = .530, Table 2 ) DMS percent correct simultaneous response (t = −1.586, p = .118, Table 2 ), DMS percent correct (t = .950, p = .436, Table 2 ), IED total error (t = .130, p = .897, Table 2 ) and IED stages completed (t = .506, p = .615, Table 2 ) between two groups.
The MMSE score was reduced in Group 2 compared to Group 1, but this difference was not significant (t = −.186, p = 0.853) ( Table 3 ).
Blood pressure (systolic and diastolic, heart rate, MMSE and stress test for two groups.
Group 1 n=35 | Group 2 n=25 | P value | |
---|---|---|---|
Mean ± SD | Mean ± SD | ||
e | |||
119.94 ± 9.65 | 122.56 ± 14.33 | 0.534 | |
72.34 ± 9.46 | 77.28 ± 8.64 | 0.044 | |
79.42 ± 13.34 | 81.68 ± 12.40 | 0.510 | |
28.47 ± 1.35 | 28.54 ± 1.47 | 0.853 | |
3.76 ± 1.01 | 4.03 ± 124 | 0.360 |
MMSE: Mini Mental Status Examination.
Participants' blood pressure was measured by using a manual sphygmomanometer. The mean systolic blood pressure in the first group was 119 mmHg, and that in the second group was 122 mmHg (t = .626, p = .534, Table 3 ). The mean diastolic blood pressure in Group 1 and Group 2 was 72 mmHg and 77 mmHg, respectively, a significant difference (t = −2.063, p = 0.04, Table 3 ). The mean of heart rate in Group 1 was 79 beats per minute, and that in Group 2 was 81 beats per minute, a non-significant difference (t = −.663, p = 0.510, Table 3 ).
There were no significant differences between Group 1 and Group 2, although body weight, BMI, fat percentage, and fat mass were higher in Group 2 ( Table 4 ).
Body composition analysis (height, weight, BMI, Fat%, Fat mass, TBW (kg) for two groups.
Group 1 n=35 | Group 2 n=25 | value | |
---|---|---|---|
Mean ± SD | Mean ± SD | ||
Height | 172.4 ± 7.42 | 170.04 ± 8.73 | 0.26 |
Weight | 74.38 ± 17.72 | 78.61 ± 26.48 | 0.46 |
BMI | 24.92 ± 4.92 | 26.78 ± 8.03 | 0.27 |
Fat% | 21.37 ± 7.79 | 24.65 ± 9.22 | 0.142 |
Fat mass | 16.57 ± 8.90 | 21.06 ± 14.53 | 0.144 |
TBWkg | 42.07 ± 8.19 | 42.14 ± 10.02 | 0.979 |
BMI: body mass index, TBW (kg): total body water.
There was no correlation between fast food consumption and abnormal lipid panel findings between the two groups (LDL, t = 0.490, p = 0.626; HDL, t = 1.080, p = 0.285; TC, t = 1.085, p = 0.283; TG, t = −0.65, p = 0.949, Table 5 ).
Blood chemistry analysis for two groups.
Group 1 n=35 | Group 2 n=25 | value | |
---|---|---|---|
Mean ± SD | Mean ± SD | ||
FBG | 4.50 ± 0.84 | 4.54 ± 0.75 | 0.68 |
TC | 4.32 ± 1.15 | 4.15 ± 0.92 | 0.283 |
TG | 1.02 ± 0.50 | 1.05 ± 0.87 | 0.94 |
LDL | 3.29 ± 0.98 | 3.29 ± 0.61 | 0.62 |
HDL | 1.28 ± 0.37 | 1.23 ± 0.28 | 0.285 |
FBG: Fasting blood glucose, TC: Total cholesterol, TG: triglycerides, LDL: low-density lipoprotein, HDL: high-density lipoprotein for two groups.
There was no statistically significant difference in the mean quality of life score between the two groups for all variable ( Table 6 ).
Quality of life questionnaire for two groups.
Group 1 n=35 | Group 2 n=25 | value | |
---|---|---|---|
Mean ± SD | Mean ± SD | ||
Total 1 | 137.48 ± 19.21 | 129.32 ± 30.07 | 0.20 |
Health 1 | 19.54 ± 0.73 | 19.60 ± 0.99 | 0.77 |
Social 1 | 19.81 ± 0.69 | 19.48 ± 0.87 | 0.10 |
Psyc 1 | 20.0 ± 0.92 | 19.74 ± 0.95 | 0.28 |
Family 1 | 20.13 ± 0.88 | 20.0 ± 1.04 | 0.59 |
Total 2 | 155.31 ± 11.93 | 158.04 ± 9.65 | 0.35 |
Health 2 | 20.44 ± 0.49 | 20.46 ± 0.43 | 0.83 |
Social 2 | 20.15 ± 0.62 | 20.15 ± 0.56 | 0.99 |
Psyc 2 | 20.73 ± 0.38 | 20.82 ± 0.25 | 0.13 |
Family 2 | 20.76 ± 0.52 | 20.84 ± 0.24 | 0.45 |
psyc: psychology.
We found that increase in an HDL significantly decreased the AST correct mean latency, the AST correct mean latency congruent and AST correct mean latency incongruent (r = −0.284, p = 0.028, r = −0.325, p = 0.011, r = −0.215, p = 0.051 respectively) ( Fig. 2 a and b, c). The result showed that an increase in QOL 1 (health) was associated with a significant reduction in stress (r = −0.432, p = 0.001, Fig. 2 d). An increase in diastolic blood pressure was significantly correlated with an increase in TC (r = 0.371, p = 0.003, Fig. 2 e). This demonstrates that increased systolic blood pressure significantly correlated with an increase in BMI (r = 0.299, p = 0.020, Fig. 2 f).
Correlation between HDL (high-density lipoprotein) and AST (cognitive attention switching) correct median latency (a).Correlation between HDL and AST correct median latency in congruent condition (b). Correlation between HDL and AST correct median latency in incongruent condition (c). Correlation between quality of life and stress (d). Correlation between diastolic blood pressure and TC (Total cholesterol) (e). Correlation between BMI (body mass index) and systolic blood pressure (f).
The result showed significant effect of fast food on metabolic function but not cognitive function in healthy population.
One study from Ye et al [35] showed cognitive impairment (mostly memory function but other domains like attention and executive function were affected as well) in middle age group taking habitual sugar intake which included fruit drinks as well as soft drinks. In that study cognitive function assessed by the MMSE significantly correlated with sugars components like sucrose, glucose, and added fructose. It showed that an increase in the consumption of added sugar was significantly associated with lower MMSE scores. This differs from our study, in which fast food consumption was not associated with a number of specific cognitive domains, including attention, memory, working memory and executive function ( Table 2 ). Our study might be different in terms of age group, fast food consumption and cognitive assessment measured tools [ 2 , 3 , 30 ]. The mechanism by which cognitive function is affected by diet is still not fully understood (Molteni et al., 2002), [25] found that HFS diet (high fat sucrose diet) was negatively associated with a decrease in hippocampal BDNF mRNA and protein, animals with higher BDNF had a better cognitive performance. Animals that were on HFS diet for a longer time exhibited lower levels of BDNF, which emphasizes on the importance of the duration of fast food consumption. The longer the duration of fast food consumption the lower the BDNF levels, although they found that 2 months on HFS diet were sufficient enough to reduce hippocampal levels of BDNF and spatial learning performance.
Our result showed metabolic difference in two groups which are in line of Raben et al. [38] study used to compare two group consume fast food for 10 weeks and increase blood pressure. The fructose in these beverages may stimulate an increase in TAG [39] , [40] . High-fructose corn syrup play major role in obesity [41] . Fast food consumption on regular basis are major player for cardio-metabolic disease, including obesity, DM2, metabolic syndrome, and cardiovascular disease [ 5 , 7 , 8 , 11 ] and all have negative impact on cognition [ 14 , 15 ], [41] . Previous study lasting 6 months showed metabolic changes (visceral, liver, and muscle fat, TAG, TC, and systolic blood pressure) [42] .
In KSA, over the past two decades, rapid economic development, global trade, and cultural exchange have meant that the FF industry and young population's FFC have been increasing rapidly. In this study, we defined Western FF as food sold in these fast food chains, e.g. KFC, McDonald's and Pizza Hut. This would make our estimate more conservative. So, we could not obtain information on the quantity of FFC, total daily energy intake, and FFC's contribution to total daily energy intake among the children. It may affect the assessment of the relationship between FFC and health outcomes.
This study has limitations which must be acknowledged. Our data is cross-sectional, and the dietary questionnaire used has a number of limitations. The sizes of fast food were not specified. Self-reported nutritional intake can lead to underestimation or overestimation of true associations, and measurement at only one point may not reflect long-term consumption patterns. Therefore, more studies, especially longitudinal studies based on large national representative samples with exact measures of quantity of fast food consume intake and its contribution to total daily energy intake, are needed to detect the association between fast food consume and health outcomes.
This is the first local cross-sectional study to examine fast food consumption and cognitive performance using a standardized battery of cognitive tests. It is very important in future to do longitudinal studies large, well-controlled, long-term interventional trials are needed locally.
In summary, the present study offers preliminary result for the effect of fast food consumption has an effect on metabolic function but has no direct effect on cognition or quality of life. More studies are warranted to understand.
For future research, we recommend that researchers should widen the study population and enroll a greater number of participants. In our study, we did not determine which cognitive domain was the most affected by fast food consumption, and thus, we encourage researchers to direct their research toward the most affected cognitive domain.
Author contribution statement.
Mohammad Alsabieh: Conceived and designed the experiments; Performed the experiments; Analyzed and interpreted the data; Wrote the paper.
Mohammad Alqahtani, Abdulaziz Altamimi: Conceived and designed the experiments; Performed the experiments; Wrote the paper.
Abdullah Albasha, Alwaleed Alsleman: Performed the experiments; Wrote the paper.
Abdullah Alkhamahi: Analyzed and interpreted the data; Wrote the paper.
Syed Shahid Habib: Contributed reagents, materials, analysis tools or data; Wrote the paper.
Shahid Bashir: Conceived and designed the experiments; Analyzed and interpreted the data; Contributed reagents, materials, analysis tools or data; Wrote the paper.
This study was supported by a grant from Deanship of Scientific Research (Grant Number: RGP-1438-048) King Saud University, Riyadh, Saudi Arabia.
The authors declare no conflict of interest.
No additional information is available for this paper.
We wish to express our sincerer gratitude to our data collectors: Ahmad Alamari, Mishari Alsalem, Faisal Alzahrani, Abdulrahman Alhooti, Hisham Almuhayzi and Mohammed Alamari. Syed Shahid Habib extend his appreciation to the Deanship of Scientific Research at King Saud University for their technical support, and for funding this work through the Grant No: RGP-1438-048. Riyadh, Saudi Arabia.
IMAGES
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ern chains has visibly coincided with the disappearance of street food. In busy market streets outside railway stations or university gates, where dozens of hawkers once sold steamed buns, tea eggs, and fried noodles, you will now find a. McDonald's, a Kentucky Frie. Chicken, or one of their many imitators. But did fast foo.
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It can provide us growth in blood stress and a high risk of coronary heart sicknesses. Obesity Fast food is allied with higher body mass index, less successful weight-loss maintenance, and weight gain. Fast food reduces the quality of the diet and provides unhealthy choices, especially raising the risk of obesity.
The sample was divided into two groups according to their fast food consumption. Group 1 included those who consumed fast food 3 times per week or less (n = 35; men = 30, women = 5), and the participants' mean age was 21.23 years. Group 2 included those who consumed fast food more than 3 times per week (n = 25; men = 21, women = 4).