COPD Case Study: Patient Diagnosis and Treatment (2024)
by John Landry, BS, RRT | Updated: May 16, 2024
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that affects millions of people around the world. It is primarily caused by smoking and is characterized by a persistent obstruction of airflow that worsens over time.
COPD can lead to a range of symptoms, including coughing, wheezing, shortness of breath, and chest tightness, which can significantly impact a person’s quality of life.
This case study will review the diagnosis and treatment of an adult patient who presented with signs and symptoms of this condition.
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COPD Clinical Scenario
A 56-year-old male patient is in the ER with increased work of breathing. He felt mildly short of breath after waking this morning but became extremely dyspneic after climbing a few flights of stairs. He is even too short of breath to finish full sentences. His wife is present in the room and revealed that the patient has a history of liver failure, is allergic to penicillin, and has a 15-pack-year smoking history. She also stated that he builds cabinets for a living and is constantly required to work around a lot of fine dust and debris.
Physical Findings
On physical examination, the patient showed the following signs and symptoms:
- His pupils are equal and reactive to light.
- He is alert and oriented.
- He is breathing through pursed lips.
- His trachea is positioned in the midline, and no jugular venous distention is present.
Vital Signs
- Heart rate: 92 beats/min
- Respiratory rate: 22 breaths/min
Chest Assessment
- He has a larger-than-normal anterior-posterior chest diameter.
- He demonstrates bilateral chest expansion.
- He demonstrates a prolonged expiratory phase and diminished breath sounds during auscultation.
- He is showing signs of subcostal retractions.
- Chest palpation reveals no tactile fremitus.
- Chest percussion reveals increased resonance.
- His abdomen is soft and tender.
- No distention is present.
Extremities
- His capillary refill time is two seconds.
- Digital clubbing is present in his fingertips.
- There are no signs of pedal edema.
- His skin appears to have a yellow tint.
Lab and Radiology Results
- ABG results: pH 7.35 mmHg, PaCO2 59 mmHg, HCO3 30 mEq/L, and PaO2 64 mmHg.
- Chest x-ray: Flat diaphragm, increased retrosternal space, dark lung fields, slight hypertrophy of the right ventricle, and a narrow heart.
- Blood work: RBC 6.5 mill/m3, Hb 19 g/100 mL, and Hct 57%.
Based on the information given, the patient likely has chronic obstructive pulmonary disease (COPD) .
The key findings that point to this diagnosis include:
- Barrel chest
- A long expiratory time
- Diminished breath sounds
- Use of accessory muscles while breathing
- Digital clubbing
- Pursed lip breathing
- History of smoking
- Exposure to dust from work
What Findings are Relevant to the Patient’s COPD Diagnosis?
The patient’s chest x-ray showed classic signs of chronic COPD, which include hyperexpansion, dark lung fields, and a narrow heart.
This patient does not have a history of cor pulmonale ; however, the findings revealed hypertrophy of the right ventricle. This is something that should be further investigated as right-sided heart failure is common in patients with COPD.
The lab values that suggest the patient has COPD include increased RBC, Hct, and Hb levels, which are signs of chronic hypoxemia.
Furthermore, the patient’s ABG results indicate COPD is present because the interpretation reveals compensated respiratory acidosis with mild hypoxemia. Compensated blood gases indicate an issue that has been present for an extended period of time.
What Tests Could Further Support This Diagnosis?
A series of pulmonary function tests (PFT) would be useful for assessing the patient’s lung volumes and capacities. This would help confirm the diagnosis of COPD and inform you of the severity.
Note: COPD patients typically have an FEV1/FVC ratio of < 70%, with an FEV1 that is < 80%.
The initial treatment for this patient should involve the administration of low-flow oxygen to treat or prevent hypoxemia .
It’s acceptable to start with a nasal cannula at 1-2 L/min. However, it’s often recommended to use an air-entrainment mask on COPD patients in order to provide an exact FiO2.
Either way, you should start with the lowest possible FiO2 that can maintain adequate oxygenation and titrate based on the patient’s response.
Example: Let’s say you start the patient with an FiO2 of 28% via air-entrainment mask but increase it to 32% due to no improvement. The SpO2 originally was 84% but now has decreased to 80%, and his retractions are worsening. This patient is sitting in the tripod position and continues to demonstrate pursed-lip breathing. Another blood gas was collected, and the results show a PaCO2 of 65 mmHg and a PaO2 of 59 mmHg.
What Do You Recommend?
The patient has an increased work of breathing, and their condition is clearly getting worse. The latest ABG results confirmed this with an increased PaCO2 and a PaO2 that is decreasing.
This indicates that the patient needs further assistance with both ventilation and oxygenation .
Note: In general, mechanical ventilation should be avoided in patients with COPD (if possible) because they are often difficult to wean from the machine.
Therefore, at this time, the most appropriate treatment method is noninvasive ventilation (e.g., BiPAP).
Initial BiPAP Settings
In general, the most commonly recommended initial BiPAP settings for an adult patient include this following:
- IPAP: 8–12 cmH2O
- EPAP: 5–8 cmH2O
- Rate: 10–12 breaths/min
- FiO2: Whatever they were previously on
For example, let’s say you initiate BiPAP with an IPAP of 10 cmH20, an EPAP of 5 cmH2O, a rate of 12, and an FiO2 of 32% (since that is what he was previously getting).
After 30 minutes on the machine, the physician requested another ABG to be drawn, which revealed acute respiratory acidosis with mild hypoxemia.
What Adjustments to BiPAP Settings Would You Recommend?
The latest ABG results indicate that two parameters must be corrected:
- Increased PaCO2
- Decreased PaO2
You can address the PaO2 by increasing either the FiO2 or EPAP setting. EPAP functions as PEEP, which is effective in increasing oxygenation.
The PaCO2 can be lowered by increasing the IPAP setting. By doing so, it helps to increase the patient’s tidal volume, which increased their expired CO2.
Note: In general, when making adjustments to a patient’s BiPAP settings, it’s acceptable to increase the pressure in increments of 2 cmH2O and the FiO2 setting in 5% increments.
Oxygenation
To improve the patient’s oxygenation , you can increase the EPAP setting to 7 cmH2O. This would decrease the pressure support by 2 cmH2O because it’s essentially the difference between the IPAP and EPAP.
Therefore, if you increase the EPAP, you must also increase the IPAP by the same amount to maintain the same pressure support level.
Ventilation
However, this patient also has an increased PaCO2 , which means that you must increase the IPAP setting to blow off more CO2. Therefore, you can adjust the pressure settings on the machine as follows:
- IPAP: 14 cmH2O
- EPAP: 7 cmH2O
After making these changes and performing an assessment , you can see that the patient’s condition is improving.
Two days later, the patient has been successfully weaned off the BiPAP machine and no longer needs oxygen support. He is now ready to be discharged.
The doctor wants you to recommend home therapy and treatment modalities that could benefit this patient.
What Home Therapy Would You Recommend?
You can recommend home oxygen therapy if the patient’s PaO2 drops below 55 mmHg or their SpO2 drops below 88% more than twice in a three-week period.
Remember: You must use a conservative approach when administering oxygen to a patient with COPD.
Pharmacology
You may also consider the following pharmacological agents:
- Short-acting bronchodilators (e.g., Albuterol)
- Long-acting bronchodilators (e.g., Formoterol)
- Anticholinergic agents (e.g., Ipratropium bromide)
- Inhaled corticosteroids (e.g., Budesonide)
- Methylxanthine agents (e.g., Theophylline)
In addition, education on smoking cessation is also important for patients who smoke. Nicotine replacement therapy may also be indicated.
In some cases, bronchial hygiene therapy should be recommended to help with secretion clearance (e.g., positive expiratory pressure (PEP) therapy).
It’s also important to instruct the patient to stay active, maintain a healthy diet, avoid infections, and get an annual flu vaccine. Lastly, some COPD patients may benefit from cardiopulmonary rehabilitation .
By taking all of these factors into consideration, you can better manage this patient’s COPD and improve their quality of life.
Final Thoughts
There are two key points to remember when treating a patient with COPD. First, you must always be mindful of the amount of oxygen being delivered to keep the FiO2 as low as possible.
Second, you should use noninvasive ventilation, if possible, before performing intubation and conventional mechanical ventilation . Too much oxygen can knock out the patient’s drive to breathe, and once intubated, these patients can be difficult to wean from the ventilator .
Furthermore, once the patient is ready to be discharged, you must ensure that you are sending them home with the proper medications and home treatments to avoid readmission.
Written by:
John Landry is a registered respiratory therapist from Memphis, TN, and has a bachelor's degree in kinesiology. He enjoys using evidence-based research to help others breathe easier and live a healthier life.
- Faarc, Kacmarek Robert PhD Rrt, et al. Egan’s Fundamentals of Respiratory Care. 12th ed., Mosby, 2020.
- Chang, David. Clinical Application of Mechanical Ventilation . 4th ed., Cengage Learning, 2013.
- Rrt, Cairo J. PhD. Pilbeam’s Mechanical Ventilation: Physiological and Clinical Applications. 7th ed., Mosby, 2019.
- Faarc, Gardenhire Douglas EdD Rrt-Nps. Rau’s Respiratory Care Pharmacology. 10th ed., Mosby, 2019.
- Faarc, Heuer Al PhD Mba Rrt Rpft. Wilkins’ Clinical Assessment in Respiratory Care. 8th ed., Mosby, 2017.
- Rrt, Des Terry Jardins MEd, and Burton George Md Facp Fccp Faarc. Clinical Manifestations and Assessment of Respiratory Disease. 8th ed., Mosby, 2019.
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Chronic obstructive pulmonary disease (COPD)
- Overview
- Theory
- Diagnosis
- Management
- Follow up
- Resources
Case history
Case history #1.
A 66-year-old man with a smoking history of one pack per day for the past 47 years presents with progressive shortness of breath and chronic cough, productive of yellowish sputum, for the past 2 years. On examination he appears cachectic and in moderate respiratory distress, especially after walking to the examination room, and has pursed-lip breathing. His neck veins are mildly distended. Lung examination reveals a barrel chest and poor air entry bilaterally, with moderate inspiratory and expiratory wheezing. Heart and abdominal examination are within normal limits. Lower extremities exhibit scant pitting edema.
Case history #2
A 56-year-old woman with a history of smoking presents to her primary care physician with shortness of breath and cough for several days. Her symptoms began 3 days ago with rhinorrhea. She reports a chronic morning cough productive of white sputum, which has increased over the past 2 days. She has had similar episodes each winter for the past 4 years. She has smoked 1 to 2 packs of cigarettes per day for 40 years and continues to smoke. She denies hemoptysis, chills, or weight loss and has not received any relief from over-the-counter cough preparations.
Other presentations
Some patients report chest tightness, which often follows exertion and may arise from intercostal muscle contraction. Weight loss, muscle loss, and anorexia are common in patients with severe and very severe COPD. [1] Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: 2024 report. 2024 [internet publication]. https://goldcopd.org/2024-gold-report Other presentations include fatigue, hemoptysis, cyanosis, and morning headaches secondary to hypercapnia. Chest pain and hemoptysis are uncommon symptoms of COPD and raise the possibility of alternative diagnoses. [2] National Institute for Health and Care Excellence. Chronic obstructive pulmonary disease in over 16s: diagnosis and management. Jul 2019 [internet publication]. https://www.nice.org.uk/guidance/ng115
Physical examination may demonstrate hypoxia, use of accessory muscles, paradoxical rib movements, distant heart sounds, lower-extremity edema and hepatomegaly secondary to cor pulmonale, and asterixis secondary to hypercapnia.
Patients may also present with signs and symptoms of COPD complications. These include severe shortness of breath, severely decreased air entry, and chest pain secondary to an acute COPD exacerbation or spontaneous pneumothorax. [1] Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: 2024 report. 2024 [internet publication]. https://goldcopd.org/2024-gold-report [3] Garcia-Pachon E. Paradoxical movement of the lateral rib margin (Hoover sign) for detecting obstructive airway disease. Chest. 2002 Aug;122(2):651-5. http://www.ncbi.nlm.nih.gov/pubmed/12171846?tool=bestpractice.com Patients with COPD often have other comorbidities, including cardiovascular disease, skeletal muscle dysfunction, metabolic syndrome and diabetes, osteoporosis, depression, anxiety, lung cancer, gastroesophageal reflux disease, bronchiectasis, obstructive sleep apnea, and cognitive impairment. [1] Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: 2024 report. 2024 [internet publication]. https://goldcopd.org/2024-gold-report [4] Morgan AD, Rothnie KJ, Bhaskaran K, et al. Chronic obstructive pulmonary disease and the risk of 12 cardiovascular diseases: a population-based study using UK primary care data. Thorax. 2018 Sep;73(9):877-9. http://www.ncbi.nlm.nih.gov/pubmed/29438071?tool=bestpractice.com [5] Maltais F, Decramer M, Casaburi R, et al; ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD. An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014 May 1;189(9):e15-62. https://www.atsjournals.org/doi/10.1164/rccm.201402-0373ST http://www.ncbi.nlm.nih.gov/pubmed/24787074?tool=bestpractice.com
One UK study found that 14.5% of patients with COPD had a concomitant diagnosis of asthma, whereas a global meta-analysis estimated the pooled prevalence of asthma in patients with COPD to be 29.6% (range: 12.6% to 55.5%). [6] Nissen F, Morales DR, Mullerova H, et al. Concomitant diagnosis of asthma and COPD: a quantitative study in UK primary care. Br J Gen Pract. 2018 Nov;68(676):e775-82. https://bjgp.org/content/68/676/e775 http://www.ncbi.nlm.nih.gov/pubmed/30249612?tool=bestpractice.com [7] Hosseini M, Almasi-Hashiani A, Sepidarkish M, et al. Global prevalence of asthma-COPD overlap (ACO) in the general population: a systematic review and meta-analysis. Respir Res. 2019 Oct 23;20(1):229. https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-019-1198-4 http://www.ncbi.nlm.nih.gov/pubmed/31647021?tool=bestpractice.com
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‘Racism absolutely must not be tolerated’
STEVE FORD, EDITOR
- You are here: COPD
Diagnosis and management of COPD: a case study
04 May, 2020
This case study explains the symptoms, causes, pathophysiology, diagnosis and management of chronic obstructive pulmonary disease
This article uses a case study to discuss the symptoms, causes and management of chronic obstructive pulmonary disease, describing the patient’s associated pathophysiology. Diagnosis involves spirometry testing to measure the volume of air that can be exhaled; it is often performed after administering a short-acting beta-agonist. Management of chronic obstructive pulmonary disease involves lifestyle interventions – vaccinations, smoking cessation and pulmonary rehabilitation – pharmacological interventions and self-management.
Citation: Price D, Williams N (2020) Diagnosis and management of COPD: a case study. Nursing Times [online]; 116: 6, 36-38.
Authors: Debbie Price is lead practice nurse, Llandrindod Wells Medical Practice; Nikki Williams is associate professor of respiratory and sleep physiology, Swansea University.
- This article has been double-blind peer reviewed
- Scroll down to read the article or download a print-friendly PDF here (if the PDF fails to fully download please try again using a different browser)
Introduction
The term chronic obstructive pulmonary disease (COPD) is used to describe a number of conditions, including chronic bronchitis and emphysema. Although common, preventable and treatable, COPD was projected to become the third leading cause of death globally by 2020 (Lozano et al, 2012). In the UK in 2012, approximately 30,000 people died of COPD – 5.3% of the total number of deaths. By 2016, information published by the World Health Organization indicated that Lozano et al (2012)’s projection had already come true.
People with COPD experience persistent respiratory symptoms and airflow limitation that can be due to airway or alveolar abnormalities, caused by significant exposure to noxious particles or gases, commonly from tobacco smoking. The projected level of disease burden poses a major public-health challenge and primary care nurses can be pivotal in the early identification, assessment and management of COPD (Hooper et al, 2012).
Grace Parker (the patient’s name has been changed) attends a nurse-led COPD clinic for routine reviews. A widowed, 60-year-old, retired post office clerk, her main complaint is breathlessness after moderate exertion. She scored 3 on the modified Medical Research Council (mMRC) scale (Fletcher et al, 1959), indicating she is unable to walk more than 100 yards without stopping due to breathlessness. Ms Parker also has a cough that produces yellow sputum (particularly in the mornings) and an intermittent wheeze. Her symptoms have worsened over the last six months. She feels anxious leaving the house alone because of her breathlessness and reduced exercise tolerance, and scored 26 on the COPD Assessment Test (CAT, catestonline.org), indicating a high level of impact.
Ms Parker smokes 10 cigarettes a day and has a pack-year score of 29. She has not experienced any haemoptysis (coughing up blood) or chest pain, and her weight is stable; a body mass index of 40kg/m 2 means she is classified as obese. She has had three exacerbations of COPD in the previous 12 months, each managed in the community with antibiotics, steroids and salbutamol.
Ms Parker was diagnosed with COPD five years ago. Using Epstein et al’s (2008) guidelines, a nurse took a history from her, which provided 80% of the information needed for a COPD diagnosis; it was then confirmed following spirometry testing as per National Institute for Health and Care Excellence (2018) guidance.
The nurse used the Calgary-Cambridge consultation model, as it combines the pathological description of COPD with the patient’s subjective experience of the illness (Silverman et al, 2013). Effective communication skills are essential in building a trusting therapeutic relationship, as the quality of the relationship between Ms Parker and the nurse will have a direct impact on the effectiveness of clinical outcomes (Fawcett and Rhynas, 2012).
In a national clinical audit report, Baxter et al (2016) identified inaccurate history taking and inadequately performed spirometry as important factors in the inaccurate diagnosis of COPD on general practice COPD registers; only 52.1% of patients included in the report had received quality-assured spirometry.
Pathophysiology of COPD
Knowing the pathophysiology of COPD allowed the nurse to recognise and understand the physical symptoms and provide effective care (Mitchell, 2015). Continued exposure to tobacco smoke is the likely cause of the damage to Ms Parker’s small airways, causing her cough and increased sputum production. She could also have chronic inflammation, resulting in airway smooth-muscle contraction, sluggish ciliary movement, hypertrophy and hyperplasia of mucus-secreting goblet cells, as well as release of inflammatory mediators (Mitchell, 2015).
Ms Parker may also have emphysema, which leads to damaged parenchyma (alveoli and structures involved in gas exchange) and loss of alveolar attachments (elastic connective fibres). This causes gas trapping, dynamic hyperinflation, decreased expiratory flow rates and airway collapse, particularly during expiration (Kaufman, 2013). Ms Parker also displayed pursed-lip breathing; this is a technique used to lengthen the expiratory time and improve gaseous exchange, and is a sign of dynamic hyperinflation (Douglas et al, 2013).
In a healthy lung, the destruction and repair of alveolar tissue depends on proteases and antiproteases, mainly released by neutrophils and macrophages. Inhaling cigarette smoke disrupts the usually delicately balanced activity of these enzymes, resulting in the parenchymal damage and small airways (with a lumen of <2mm in diameter) airways disease that is characteristic of emphysema. The severity of parenchymal damage or small airways disease varies, with no pattern related to disease progression (Global Initiative for Chronic Obstructive Lung Disease, 2018).
Ms Parker also had a wheeze, heard through a stethoscope as a continuous whistling sound, which arises from turbulent airflow through constricted airway smooth muscle, a process noted by Mitchell (2015). The wheeze, her 29 pack-year score, exertional breathlessness, cough, sputum production and tiredness, and the findings from her physical examination, were consistent with a diagnosis of COPD (GOLD, 2018; NICE, 2018).
Spirometry is a tool used to identify airflow obstruction but does not identify the cause. Commonly measured parameters are:
- Forced expiratory volume – the volume of air that can be exhaled – in one second (FEV1), starting from a maximal inspiration (in litres);
- Forced vital capacity (FVC) – the total volume of air that can be forcibly exhaled – at timed intervals, starting from a maximal inspiration (in litres).
Calculating the FEV1 as a percentage of the FVC gives the forced expiratory ratio (FEV1/FVC). This provides an index of airflow obstruction; the lower the ratio, the greater the degree of obstruction. In the absence of respiratory disease, FEV1 should be ≥70% of FVC. An FEV1/FVC of <70% is commonly used to denote airflow obstruction (Moore, 2012).
As they are time dependent, FEV1 and FEV1/FVC are reduced in diseases that cause airways to narrow and expiration to slow. FVC, however, is not time dependent: with enough expiratory time, a person can usually exhale to their full FVC. Lung function parameters vary depending on age, height, gender and ethnicity, so the degree of FEV1 and FVC impairment is calculated by comparing a person’s recorded values with predicted values. A recorded value of >80% of the predicted value has been considered ‘normal’ for spirometry parameters but the lower limit of normal – equal to the fifth percentile of a healthy, non-smoking population – based on more robust statistical models is increasingly being used (Cooper et al, 2017).
A reversibility test involves performing spirometry before and after administering a short-acting beta-agonist (SABA) such as salbutamol; the test is used to distinguish between reversible and fixed airflow obstruction. For symptomatic asthma, airflow obstruction due to airway smooth-muscle contraction is reversible: administering a SABA results in smooth-muscle relaxation and improved airflow (Lumb, 2016). However, COPD is associated with fixed airflow obstruction, resulting from neutrophil-driven inflammatory changes, excess mucus secretion and disrupted alveolar attachments, as opposed to airway smooth-muscle contraction.
Administering a SABA for COPD does not usually produce bronchodilation to the extent seen in someone with asthma: a person with asthma may demonstrate significant improvement in FEV1 (of >400ml) after having a SABA, but this may not change in someone with COPD (NICE, 2018). However, a negative response does not rule out therapeutic benefit from long-term SABA use (Marín et al, 2014).
NICE (2018) and GOLD (2018) guidelines advocate performing spirometry after administering a bronchodilator to diagnose COPD. Both suggest a FEV1/FVC of <70% in a person with respiratory symptoms supports a diagnosis of COPD, and both grade the severity of the condition using the predicted FEV1. Ms Parker’s spirometry results showed an FEV1/FVC of 56% and a predicted FEV1 of 57%, with no significant improvement in these values with a reversibility test.
GOLD (2018) guidance is widely accepted and used internationally. However, it was developed by medical practitioners with a medicalised approach, so there is potential for a bias towards pharmacological management of COPD. NICE (2018) guidance may be more useful for practice nurses, as it was developed by a multidisciplinary team using evidence from systematic reviews or meta-analyses of randomised controlled trials, providing a holistic approach. NICE guidance may be outdated on publication, but regular reviews are performed and published online.
NHS England (2016) holds a national register of all health professionals certified in spirometry. It was set up to raise spirometry standards across the country.
Assessment and management
The goals of assessing and managing Ms Parker’s COPD are to:
- Review and determine the level of airflow obstruction;
- Assess the disease’s impact on her life;
- Risk assess future disease progression and exacerbations;
- Recommend pharmacological and therapeutic management.
GOLD’s (2018) ABCD assessment tool (Fig 1) grades COPD severity using spirometry results, number of exacerbations, CAT score and mMRC score, and can be used to support evidence-based pharmacological management of COPD.
When Ms Parker was diagnosed, her predicted FEV1 of 57% categorised her as GOLD grade 2, and her mMRC score, CAT score and exacerbation history placed her in group D. The mMRC scale only measures breathlessness, but the CAT also assesses the impact COPD has on her life, meaning consecutive CAT scores can be compared, providing valuable information for follow-up and management (Zhao, et al, 2014).
After assessing the level of disease burden, Ms Parker was then provided with education for self-management and lifestyle interventions.
Lifestyle interventions
Smoking cessation.
Cessation of smoking alongside support and pharmacotherapy is the second-most cost-effective intervention for COPD, when compared with most other pharmacological interventions (BTS and PCRS UK, 2012). Smoking cessation:
- Slows the progression of COPD;
- Improves lung function;
- Improves survival rates;
- Reduces the risk of lung cancer;
- Reduces the risk of coronary heart disease risk (Qureshi et al, 2014).
Ms Parker accepted a referral to an All Wales Smoking Cessation Service adviser based at her GP surgery. The adviser used the internationally accepted ‘five As’ approach:
- Ask – record the number of cigarettes the individual smokes per day or week, and the year they started smoking;
- Advise – urge them to quit. Advice should be clear and personalised;
- Assess – determine their willingness and confidence to attempt to quit. Note the state of change;
- Assist – help them to quit. Provide behavioural support and recommend or prescribe pharmacological aids. If they are not ready to quit, promote motivation for a future attempt;
- Arrange – book a follow-up appointment within one week or, if appropriate, refer them to a specialist cessation service for intensive support. Document the intervention.
NICE (2013) guidance recommends that this be used at every opportunity. Stead et al (2016) suggested that a combination of counselling and pharmacotherapy have proven to be the most effective strategy.
Pulmonary rehabilitation
Ms Parker’s positive response to smoking cessation provided an ideal opportunity to offer her pulmonary rehabilitation (PR) – as indicated by Johnson et al (2014), changing one behaviour significantly increases a person’s chance of changing another.
PR – a supervised programme including exercise training, health education and breathing techniques – is an evidence-based, comprehensive, multidisciplinary intervention that:
- Improves exercise tolerance;
- Reduces dyspnoea;
- Promotes weight loss (Bolton et al, 2013).
These improvements often lead to an improved quality of life (Sciriha et al, 2015).
Most relevant for Ms Parker, PR has been shown to reduce anxiety and depression, which are linked to an increased risk of exacerbations and poorer health status (Miller and Davenport, 2015). People most at risk of future exacerbations are those who already experience them (Agusti et al, 2010), as in Ms Parker’s case. Patients who have frequent exacerbations have a lower quality of life, quicker progression of disease, reduced mobility and more-rapid decline in lung function than those who do not (Donaldson et al, 2002).
“COPD is a major public-health challenge; nurses can be pivotal in early identification, assessment and management”
Pharmacological interventions
Ms Parker has been prescribed inhaled salbutamol as required; this is a SABA that mediates the increase of cyclic adenosine monophosphate in airway smooth-muscle cells, leading to muscle relaxation and bronchodilation. SABAs facilitate lung emptying by dilatating the small airways, reversing dynamic hyperinflation of the lungs (Thomas et al, 2013). Ms Parker also uses a long-acting muscarinic antagonist (LAMA) inhaler, which works by blocking the bronchoconstrictor effects of acetylcholine on M3 muscarinic receptors in airway smooth muscle; release of acetylcholine by the parasympathetic nerves in the airways results in increased airway tone with reduced diameter.
At a routine review, Ms Parker admitted to only using the SABA and LAMA inhalers, despite also being prescribed a combined inhaled corticosteroid and long-acting beta 2 -agonist (ICS/LABA) inhaler. She was unaware that ICS/LABA inhalers are preferred over SABA inhalers, as they:
- Last for 12 hours;
- Improve the symptoms of breathlessness;
- Increase exercise tolerance;
- Can reduce the frequency of exacerbations (Agusti et al, 2010).
However, moderate-quality evidence shows that ICS/LABA combinations, particularly fluticasone, cause an increased risk of pneumonia (Suissa et al, 2013; Nannini et al, 2007). Inhaler choice should, therefore, be individualised, based on symptoms, delivery technique, patient education and compliance.
It is essential to teach and assess inhaler technique at every review (NICE, 2011). Ms Parker uses both a metered-dose inhaler and a dry-powder inhaler; an in-check device is used to assess her inspiratory effort, as different inhaler types require different inhalation speeds. Braido et al (2016) estimated that 50% of patients have poor inhaler technique, which may be due to health professionals lacking the confidence and capability to teach and assess their use.
Patients may also not have the dexterity, capacity to learn or vision required to use the inhaler. Online resources are available from, for example, RightBreathe (rightbreathe.com), British Lung Foundation (blf.org.uk). Ms Parker’s adherence could be improved through once-daily inhalers, as indicated by results from a study by Lipson et al (2017). Any change in her inhaler would be monitored as per local policy.
Vaccinations
Ms Parker keeps up to date with her seasonal influenza and pneumococcus vaccinations. This is in line with the low-cost, highest-benefit strategy identified by the British Thoracic Society and Primary Care Respiratory Society UK’s (2012) study, which was conducted to inform interventions for patients with COPD and their relative quality-adjusted life years. Influenza vaccinations have been shown to decrease the risk of lower respiratory tract infections and concurrent COPD exacerbations (Walters et al, 2017; Department of Health, 2011; Poole et al, 2006).
Self-management
Ms Parker was given a self-management plan that included:
- Information on how to monitor her symptoms;
- A rescue pack of antibiotics, steroids and salbutamol;
- A traffic-light system demonstrating when, and how, to commence treatment or seek medical help.
Self-management plans and rescue packs have been shown to reduce symptoms of an exacerbation (Baxter et al, 2016), allowing patients to be cared for in the community rather than in a hospital setting and increasing patient satisfaction (Fletcher and Dahl, 2013).
Improving Ms Parker’s adherence to once-daily inhalers and supporting her to self-manage and make the necessary lifestyle changes, should improve her symptoms and result in fewer exacerbations.
The earlier a diagnosis of COPD is made, the greater the chances of reducing lung damage through interventions such as smoking cessation, lifestyle modifications and treatment, if required (Price et al, 2011).
- Chronic obstructive pulmonary disease is a progressive respiratory condition, projected to become the third leading cause of death globally
- Diagnosis involves taking a patient history and performing spirometry testing
- Spirometry identifies airflow obstruction by measuring the volume of air that can be exhaled
- Chronic obstructive pulmonary disease is managed with lifestyle and pharmacological interventions, as well as self-management
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Major Case Study: COPD
Feb 20, 2012
400 likes | 906 Views
Major Case Study: COPD. Emily Brantley Dietetic Intern Andrews University. Patient’s Initials: NM Primary Problem & other medical conditions: COPD , DM, IBS, Pneumonia, IgA deficiency Height: 160.02 Weight: 107.2 Age: 62 years old Sex: Female. Introduction. Introduction.
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Presentation Transcript
Major Case Study: COPD Emily Brantley Dietetic Intern Andrews University
Patient’s Initials: NM Primary Problem & other medical conditions: COPD, DM, IBS, Pneumonia, IgA deficiency Height: 160.02 Weight: 107.2 Age: 62 years old Sex: Female Introduction
Introduction • Reason patient was chosen for case study: • NM was chosen because of the multiple complications that she faces. • Date the study began and ended • December 5, 2013 – December 6, 2013 • Focus of this study: • Chronic Obstructive Pulmonary Disease (COPD) • NM has other comorbidities, however, NM is most often admitted to the hospital for exacerbation of COPD.
Social History • NM is a Christian woman who lives at home with her husband and pet parakeet. • She is currently on Medicare. • Retired RN. • Her three children are all adults and live within the region. • NM is a former smoker • Medical records indicate that she does not smoke or drink alcohol anymore.
Normal Anatomy and Physiology of Applicable Body Functions • COPD is characterized by slow, progressive obstruction of the airways. • There are two physical conditions that make up COPD. • Emphysema • Characterized by abnormal, permanent enlargement and destruction of the alveoli • Chronic Bronchitis • A progressive cough with inflammation of bronchi and other lung changes • Frequently, both illnesses coexist as part of this disorder. • In both cases, the disease limits the airflow 1&2
Past Medical History
Past Medical History • NM initially received the diagnosis of COPD in 1997. • American Thoracic Society states comorbidities such as cardiac disease, diabetes mellitus, hypertension, and psychological disorders are commonly reported in patients with COPD, but with great variability in reported prevalence.
Past Medical History • Pneumonia • NM has been hospitalized six times within the past year for episodes of pneumonia. • COPD is more frequently associated with pneumonia. • Corticosteroids are standard of care for acute exacerbations of COPD, but their role in the management of patients with COPD with pneumonia is less defined. 3 • Diabetes Mellitus. • The evidence for an interaction between diabetes and COPD is supported by studies that demonstrate reduced lung function as a risk factor for the development of diabetes. • Smoking has been established as a risk factor for both COPD and Diabetes Mellitus. 3 • Gastro-esophageal reflux disease (GERD). • An increased prevalence of GERD has been reported in patients with COPD. A study of 421 patients with severe COPD using 24-hour esophageal pH monitoring showed that 62% had pathological GERD, and 58% of the patients reported no symptoms of GERD.3
Past Medical History • Bronchial Asthma • Adrenal Insufficiency • Coronary Artery Disease • Trachaeomalacia • Addison’s disease • Hypothyroidism • Bipolar Disorder • Irritable Bowel syndrome • Vascular stent placement • Hyperlipidemia • Hyperthyroidism • Anemia
Present Medical Status and Treatment
Theoretical Discussion of Disease Condition • COPD is the fourth leading cause of death in America. COPD is also more prevalent in women.3&4 • The primary risk factor in the development of COPD is smoking. • Beyond the cessation of smoking, it has been shown that the inflammatory stress continues to damage the lung tissue. • Other risk factors include air pollution, secondhand smoke, history of childhood infections, and occupational exposure to certain industrial pollutants.
Theoretical Discussion of Disease Condition • Although normal lung function gradually declines with age, individuals who are smokers have a more rapid decline—twice the rate of nonsmokers. • Low body weight has also been shown to be a risk factor for the development of COPD even after adjusting for other potential risk factors including smoking and age.2 • Malnourished patients with COPD experience worsened respiratory muscle strength, decreased ventilator drive and response to hypoxia, and altered immune function.1,5&6
Usual Treatment of the Condition • An early and accurate diagnosis of COPD is the key to treatment. • Quitting smoking is the single most important thing that can be done to help treat COPD.7 • The usual treatment of COPD is composed of four main goals for effective management: • 1. Assess and monitor the disease • 2. Reduce risk factors • 3. Maintain stable COPD and respiratory status • 4. Manage any exacerbations • Once the disease progresses, rehabilitation programs along with oxygen therapy are used as treatment. • Medications include bronchodilators, glucocorticosteroids, mucolytic agents, and antibiotics to treat infections. • In cases where COPD may be advanced, there is an option for surgical intervention, such as a lung transplant.1
Patient’s Symptoms upon Admission Leading to Present Diagnosis • NM was admitted with shortness of breath, cough, diarrhea, hypokalemia and fever. • She revealed that one of the possible causes of her diarrhea may be the fact that she had “been around a couple of people with Clostridium Difficile.” • NM also showed symptoms of hyperlipidemia and hypertension • High blood pressure is a complication of COPD.6 • Hyperglycemia is a side effect of steroid therapy for COPD. • Steroids can increase the blood sugar making diabetes harder to control.8
Laboratory Findings and Interpretation
Current Medications • Depakote ER (Valproic Acid) • Lexapro (Escitaloprem) • Florinef (Fludrocortison Acitate) • Fluticasone- salmeterol • Metronidazole Flagyl • Insulin Lispro (Humalog) • Misoprostal (Cytotec) • Monelukast (Singulair) • Pantaprazole (Protonix oral) • Potassium Chloride • RisperiDONE (RisperDAL) • Rosuvastatin (Crestor) • NaCl • Tolterodine • Voriconazole
Observable Physical and Psychological Changes in Patient • NM physically looked well nourished. • She did not appear to have difficulty breathing until after she spoke for a long period of time. • She did have a severe cough that she tried to conceal. • NM was a very agreeable patient for both psychological interviews. • In spite of her COPD diagnosis and all of the multiple medical comorbidities that NM faced, she still presented a positive attitude and spoke openly about her faith.
Treatment • NM received a chest x ray that revealed consolidation in the left lung and midline lung level. • Once this was identified, she was admitted to the hospital from the Emergency room for treatment. • She was started on IV steroids, IV antibiotics, flagyl and nebulizers around the clock to see how she progressed.
Medical Nutrition Therapy
Nutrition History • Beginning in March 2012, NM began intentionally losing weight by following a PCP prescribed commercial diet known as Optifast. • Optifast offers shakes, protein bars and soups. • With this regimen, NM has lost 70 pounds since March 2012. • At home, NM usually sticks to her Optifast food items for breakfast, lunch and snacks between meals. • For dinner, she shares a meal with her husband. • He is a professional chef who is control of purchasing groceries and prepares dinner most nights.
Analysis of Previous Diet: 24 hour recall
Current Prescribed Diet • NM was on steroid therapy to treat her COPD. • Because of the steroid therapy, NM was admitted with consistently high blood glucose levels. • For this reason, doctor’s orders were given for an Average Diabetic Diet for the duration of her stay at Winter Park Memorial Hospital. • An Average Diabetic Diet provides a consistent 60-75 grams of carbohydrates for each meal. • NM’s diet order remained the same for her entire stay.
Objectives of Dietary Treatment • The objective of the Average Diabetic diet is to maintain NM’s blood sugars within normal limits or as close as possible to normal levels. • Steroid therapy that NM was undergoing to treat her COPD helps keep blood sugars high • Finger-stick blood sugar levels referred to as “Accuchecks” ranged inconsistently from 130 to 289 as seen on the lab values table above.
Patient’s Physical and Psychological Response to Diet • At home, NM followed an eating pattern similar to that of the Average Diabetic Diet but with the addition of snacks in between meals. • She denied facing vomiting or constipation while on this diet. • She did admit to experiencing diarrhea and nausea upon admission to the hospital. • As previously mentioned, NM believed she was exposed to Clostridium Difficile, to which she attributes to the cause of having diarrhea.
List nutrition-related problems with supporting evidence • COPD: Increased energy expenditure related to increased energy requirements during COPD exacerbation as evidenced by measured resting energy expenditure greater than predicted needs.
Evaluation of Present Nutritional Status • According to the diet analysis table, NM was meeting her increased caloric needs for COPD. • Her diarrhea subsided by day two of hospitalization. • Per lab values as those noted above in the table, there did not appear to be any indication of dehydration.
Calorie and Protein Guidelines • Nutritional needs are often increased in COPD due to the increased work of breathing. • Optimal nutritional status plays an important role in maintaining the integrity of the respiratory system and in allowing maximal participation in daily living.1 • Caloric requirements for COPD individually determined based on: • Patient age, weight and gender, the extent of protein energy malnutrition loss of lean body mass, current medications and other acute or chronic medical conditions. • The Mifflin St. Jeor equation may underestimate the caloric requirements of patient’s with COPD because of the caloric increase from metabolically active tissue. • To compensate for this underestimation, a stress activity factor may be added according to the degree of stress. • In most cases the total calorie intake of the COPD patient is more important than the source from calories.
Calorie and Protein Guidelines • For maintenance 1.33 x REE or 25/35 calories per kilogram is appropriate for the needs of the COPD patient. • Protein is recommended at 1.0-1.5 grams per kilogram of body weight for maintenance.1 • Below is a chart of how NM’s needs were clinically calculated during her hospital admission on December 5th through the 6th.
Need for Alternative Feeding Methods and the Patient’s Nutrition Education Process • NM was in fact meeting the additional needs required for COPD, I do not believe that there was any need for alternative feedings such as tube feeding. • Moreover, in explaining the prescribed diabetic diet to NM, no type of barrier to learning was identified.
Prognosis • NM expressed her motivation to continue to follow a diet similar to that of the Average Diabetic Diet upon her return home as long as her increased COPD needs were met. • She was aware of the effects of steroid therapy on her blood sugar levels. • NM clearly verbalized her understanding on the use of steroids, their effects on increasing blood sugar levels and the importance of meal planning especially around carbohydrates. • This was more of a motivating factor for her to continue monitoring her diet on discharge.
Summary • From this study, I learned how very serious COPD is. • It was once explained to me some time ago that COPD was like a gradual suffocating in a pillow. • Seeing NM experiencing shortness of breath during the interviews or when speaking to me during the interviews made me realize that even the slightest amount of energy requires oxygen. • Imagine not being able to breathe to conduct the simplest activities of daily living! • In addition to other medical issues as NM had, it made me realize how important nutrition energy is needed for healing.
Thank You!
References • Mahan LK, Escott-Stump S, Raymond JL. Krause’s Food, Nutrition and Diet Therapy, 13th Edition, Philadelphia, Pa: Elsevier; 2012 • Nelms M, Sucher KP, Lacey K, Roth SL. Nutrition Therapy and Pathophysiology, 2nd Edition. Cengage Learning, Inc: 2010. • Chatila WM, Thomashow BM, Make BJ. Comorbidities in Chronic Obstructive Pulmonary Disease. Journal of the American Thoracic Society. 2008 May 1; 5(4): 549-555 • Centers for Disease Control. Chronic Obstructive Pulmonary Disease (COPD) Data and Statistics. Available at: http://www.cdc.gov/copd/data.htm. Accessed December 29, 2013. • American Society for Parenteral and Enteral Nutrition. Disease-Related Malnutrition and Enteral Nutrition Therapy. Available at: http://www.nutritioncare.org/index.aspx?id=5696. Accessed January 5, 2014. • Mayo Clinic. Disease and Conditions: COPD. Available at: http://www.mayoclinic.org/diseases-conditions/seo/basics/symptoms/con-20032017. Accessed January 8, 2014. • National Institutes of Health: National Heart Lung and Blood Institute. How Is COPD Treated? Available at: http://www.nhlbi.nih.gov/health/health-topics/topics/copd/treatment.html. Accessed January 8, 2014. • British Lung Foundation. Steroids. Available at: http://www.blf.org.uk/Page/Steroids. Accessed December 29, 2013. • MedlinePlus: A service of the U.S. National Library of Medicine From the National Institutes of Health National Institutes of Health. Drugs and Supplements. Available at: http://www.nlm.nih.gov/medlineplus/druginfo/drug_Ca.html • U.S. National Library of Medicine. Drug Information from the National Library of Medicine. Available at: https://www.nlm.nih.gov/learn-about-drugs.html. Accessed January 8, 2014. • Optifast. Product Information. Available at: http://www.optifast.com/Pages/index.aspx. Accessed January 7, 2014
References: Images • http://sciencelife.uchospitals.edu/2013/05/07/qa-dr-christopher-wigfield-on-the-future-of-lung-transplantation/ • http://www.guidantwealth.com/Goal-early-retirement.html • http://www.recessionista.com • http://www.everydayhealth.com • https://www.spiriva.com/?sc=SPRACQWEBPGOGBS1105034&utm_source=google&utm_medium=cpc&utm_term=spiriva&utm_campaign=Branded&MTD=2&ENG=1 • http://www.nlm.nih.gov/medlineplus/ency/imagepages/19376.htm • http://www.cdc.gov/copd/data.htm • http://www.www.kingcounty.gov • http://www.www.anactivelife.com • http://www.optifast.com/Pages/index.aspx • www.fairmed.at • www. Eatright.org • http://www.alltheweigh.com
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- Published: 28 August 2024
Clinical and radiological features associated with rupture of pulmonary artery pseudoaneurysm: a retrospective study
- Min Liu 1 na1 ,
- Jixiang Liu 1 na1 ,
- Wei Yu 2 na1 ,
- Xiaoyan Gao 2 ,
- Shi Chen 2 ,
- Wei Qin 2 ,
- Ziyang Zhu 2 ,
- Chenghong Li 2 , 3 ,
- Fajiu Li 2 &
- Zhenguo Zhai 1
BMC Pulmonary Medicine volume 24 , Article number: 417 ( 2024 ) Cite this article
Metrics details
Hemoptysis resulting from rupture of the pulmonary artery pseudoaneurysm (PAP) is massive and fatal, while factor contributing to the rupture of pseudoaneurysm remains elusive. This study aimed to elucidate the clinical and radiological features of PAP and identify the risk factors associated with rupture.
Patients who developed hemoptysis with PAP were collected from January 2019 to December 2022 retrospectively. Clinical data of the demographic characteristics, radiological findings, treatment strategies, and prognosis were collected. A comparative analysis was performed on the characteristics in the ruptured and non-ruptured cases.
A total of 58 PAPs were identified in the 50 patients. The most common causes were infection (86%) and cancer (8%). The PAPs were located predominantly in the upper lobes of both lungs, and 57 (99.3%) were distributed in the segmental or subsegmental pulmonary arteries. The median diameter was 6.1(4.3–8.7) mm. A total of 29 PAPs were identified adjacent to pulmonary cavitations, with the median diameter of the cavity being 18.9 (12.4–34.8) mm. Rupture of pseudoaneurysm occurred in 21 cases (42%). Compared to unruptured group, the ruptured group had a significantly higher proportion of massive hemoptysis (57.1% vs. 6.9%, p < 0.001), larger pseudoaneurysm diameter (8.1 ± 3.2 mm vs. 6.0 ± 2.3 mm, p = 0.012), higher incidence of pulmonary cavitation (76.2% vs. 44.8%, p = 0.027), and larger cavitation diameters (32.9 ± 18.8 mm vs. 15.7 ± 8.4 mm, p = 0.005). The mean pulmonary artery pressure (mPAP) in the ruptured group was also significantly higher than that in the unruptured group [23.9 ± 7.4 mmHg vs. 19.2 ± 5.0 mmHg, p = 0.011]. Endovascular treatment was successfully performed in all 21 patients with ruptured PAP, of which the clinical success rate was 96.0%. Five patients experienced recurrent hemoptysis within one year.
Conclusions
Massive hemoptysis, pseudoaneurysm diameter, pulmonary cavitation, and elevated mPAP were the risk factors for rupture of pseudoaneurysm. Our findings facilitate early identification and timely intervention of PAP at high risk of rupture.
Peer Review reports
Hemoptysis is a serious clinical complication, which can be fatal. The source of hemorrhage is mainly the bronchial artery. Hemoptysis due to pulmonary arterial origin is quite rare and it is estimated to occur in less than 10% of cases [ 1 ]. Pulmonary artery pseudoaneurysm (PAP) is one of causes associated with pulmonary artery. Histologically, a pseudoaneurysm comprises either the media, adventitia, or the soft tissue surrounding the vessel, unlike a true aneurysm which involves all three layers of the artery. As a consequence, the pseudoaneurysm has a higher risk of rupture [ 2 ]. Hemoptysis has been described as a possible warning sign for rupture of PAP. In patients with massive hemoptysis undergoing bronchial artery embolization, 5-11% patients result from PAP rupture [ 3 ]. Once PAP ruptures, the mortality can be as high as 50% [ 4 ]. Therefore, risk assessment of the rupture of PAP is critical for early identification.
As low incidence and asymptomatic manifestation, patients with PAP are frequently underdiagnosis or misdiagnosed. PAP may be congenital or acquired. It has been found that PAP was associated with infection, primary or metastatic lung neoplasm, traumatic injury, pulmonary arterial hypertension, or vasculitis [ 5 , 6 ]. Previous case series have reported that pseudoaneurysms secondary to aspergillus and tumors both tend to be adjacent to cavitary lesion [ 4 , 7 ]. Rasmussen’s aneurysms were often accompanied by tuberculous cavities, which appeared to be more prone to rupture and cause fatal hemoptysis [ 4 ]. However, it remains uncertain whether the cavitary lesions and the rupture are clinically related.
The diameter of abdominal aortic aneurysm (AAA) has been well-established as a crucial determinant and independent predictor of AAA rupture [ 8 ]. A reliable assessment of hemodynamics is also crucial for predicting the risk of AAA rupture [ 9 ]. Nevertheless, the relationship between pseudoaneurysm size and hemodynamics and PAP rupture has rarely been discussed. Currently, only case reports and series have described the etiology and radiological features. Little is known about the relevant factors for rupture of pseudoaneurysm in the lung. Therefore, this study aimed to illustrate the clinical characteristics of the rupture of pseudoaneurysm in a single center and further identify patients at high risk of rupture for early intervention.
Study population
Clinical data were collected from individuals who underwent computed tomography angiography (CTA) or transcatheter pulmonary vascular intervention for hemoptysis between January 2019 and December 2022. The medical data collected included age, gender, clinical symptoms, medical history, volume of hemoptysis, underlying etiology, imaging characteristics, and intervention and treatment outcomes. Hemoptysis was defined as mild (≤ 39 ml/day), moderate (40–199 ml/day), or massive (≥ 200 ml/day) [ 10 ]. The study received approval from institutional review boards for the retrospective review of electronic records and imaging (WHSHIRB-K-2022004). Written informed consent was obtained from each participant.
Imaging findings
Computed tomography angiography
A 64-detector CT scanner was used to conduct CTA, from the thoracic inlet to a position 5–10 cm above the upper abdomen, employing a slice thickness of 1.00 mm. PAP was identified as focal dilations of the pulmonary artery. Information regarding the location, number, size, and level of PAP was collected systematically. Other CT findings, such as cavitations adjacent to PAP were also documented. The size of the PAP was determined using the longest diameter observed on the axial CT scan [ 11 ]. The size of the cavitation was measured based on its maximum diameter [ 12 ].
Digital subtraction angiography
All of the patients underwent bronchial and non-bronchial systemic collateral arterial angiography to identify the target vessels of hemoptysis. Right heart catheterization was conducted during digital subtraction angiography (DSA). This procedure involved measuring pressures at various sites and calculating the cardiac output (CO) using thermodilution. Pulmonary angiography was performed initially at the bifurcation of the right or left pulmonary artery to demonstrate the presence of any PAP and to delineate the anatomy of the pulmonary artery. Selective segmental or subsegmental angiography was performed to determine the location and feeding vessel.
Based on imaging from CTA and DSA, the PAPs were classified into four types. Type A can be visualized by non-selective pulmonary arteriography, type B by selective segmental or subsegmental pulmonary arteriography, type C by bronchial and non-bronchial systemic arteriography, while type D is only visible on pulmonary CT angiography and not on catheter-directed angiography [ 13 ]. If a PAP was not visualized on CTA but appeared on DSA pulmonary angiography, the maximum diameter of the PAP observed by DSA was measured to determine its size. The criteria of identification of rupture: (1) the presence of pseudoaneurysm and extravasation of contrast agent in angiography. (2) no signs of bronchial artery rupture were observed during angiography in patients with paroxysmal hemoptysis. (3) cessation or significant reduction of hemoptysis after embolization.
Treatment methods
A 5 F angiography catheter (Cook, USA) was superselected into the feeding vessels of the PAP and a 1.98 F microcatheter (Asahi, Japan) was superselected into the pseudoaneurysm sac to embolize with the coil. In a case in which the microcatheter could not reach the aneurysm sac, a pseudoaneurysm was excluded by coil embolization of the feeding vessel. The neck of the pseudoaneurysm was embolized when the pseudoaneurysm sac was too large to embolize fully. Patients were observed for 72 h postoperatively to assess complications and treatment effects. The evaluation of PAP embolization included technical success and clinical success [ 14 ]. Technical success was defined as a pseudoaneurysm no longer visible after embolization, while clinical success was defined as cessation of hemoptysis or a significant reduction after the procedure.
Statistical analyses
All the statistical analyses were conducted using SPSS (version 24.0, IBM Corp). The data were expressed as either median and the first and third quartiles (Q1-Q3), mean ± standard deviation (SD), or absolute number and percentage of patients. For normally distributed data, the t-test was used to compare differences between the two groups. If the data were non-normally distributed, the Mann-Whitney U test was performed. Chi-square (χ2) tests or Fisher exact tests were used to compare proportions between the two groups. Statistical significance was defined as p < 0.05.
From January 2019 to December 2022, a total of 2782 inpatients presented with hemoptysis. PAP was detected in 50 cases by pulmonary artery CTA or DSA arteriography. The flowchart for selecting the study population is shown in Fig. 1 . The baseline characteristics of these patients are summarized in Table 1 . The mean age was 62.1 ± 13.4 years, with 36 (72%) of them being male. The proportion of patients with massive hemoptysis was 14 (28%), and three of them received preoperative endotracheal intubation due to asphyxia. The cause of PAP is listed in Table 2 . Notably, the most common causes were infection and pulmonary malignancy. Infection was presented in 43 cases (86%), including obsolete and active tuberculosis (40% and 12%, respectively), bronchiectasis (12%), and focal pneumonia (8%). Fungal infection was observed in 5 patients (10%) and 3 of them were identified as Aspergillus infection through sputum culture (Fig. 2 ). Four cases (8%) were caused by malignant tumors, including primary lung cancer and liver cancer with lung metastasis.
The flowchart of selecting the study population
Representative images of Aspergillus infection combined with pulmonary artery pseudoaneurysm. A 48-year-old male was admitted with massive hemoptysis. Sputum culture confirmed aspergillus infection. Bronchial artery embolization was performed six months ago due to hemoptysis. ( A ) The axial enhanced CT scan reveals a PAP (arrow) located in the segmental pulmonary artery of the right upper lobe. The PAP is accompanied by cavitary lesions; ( B ) The axial enhanced CT scan displayed a crescent-shaped cavity (red arrow) in the right upper lobe, indicating a typical imaging manifestation of aspergillus infection; ( C ) Selective subsegmental pulmonary artery angiography confirmed the PAP (arrow); ( D ) The aneurysmal sac (arrow) was embolized with coils
Imaging features
A total of 58 PAPs were identified in all the patients with hemoptosis. The imaging features are detailed in Table 3 . The PAPs were located primarily in the upper lobes of the lungs, with 24 (41.4%) in the left upper lobe, and 18 (31.0%) in the right upper lobe. They had a strong predilection for the peripheral pulmonary arteries and 57 (99.3%) were located in the segmental or subsegmental pulmonary arteries. The median diameter of PAP was 6.1(4.3–8.7) mm, and the maximum diameter was 15.2 mm. A total of 29 PAPs were identified adjacent to pulmonary cavitations (Fig. 3 ). The median diameter of the cavity was 18.9 (12.4–34.8) mm, with the maximum diameter being 77.4 mm. Four cases (8%) coexisted with bronchial artery aneurysms. pseudoaneurysm in 21 cases (42%) were considered as ruptured, of which most presented massive hemoptysis (Fig. 4 ).
Representative images of tuberculous cavity combined with pulmonary artery pseudoaneurysm. A 54-year-old male was admitted to the hospital due to massive hemoptysis. He was diagnosed with sputum smear-positive pulmonary tuberculosis. ( A ) Axial contrast-enhanced CT scan shows a pseudoaneurysm (arrow) in the segmental pulmonary artery of the left upper lobe; ( B ) Axial contrast-enhanced CT scan shows a large cavitary lesion (red arrow) adjacent to the PAP
Representative images of ruptured pulmonary artery pseudoaneurysm. A 76-year-old male was hospitalized due to sudden massive hemoptysis. The patient had a history of tuberculosis and a positive sputum smear indicated the recurrence of tuberculosis. ( A ) Axial contrast-enhanced CT scan shows a pseudoaneurysm (arrow) distributed in the segmental pulmonary artery of the left upper lobe; ( B ) Axial contrast-enhanced CT scan shows that the PAP is adjacent to a cavitary lesion (red arrow); ( C ) Selective subsegmental pulmonary arteriography shows contrast agent extravasation from the PAP to the cavity (arrow) and trachea (arrowhead), confirming its rupture; ( D ) Final angiography shows occlusion of pseudoaneurysm (arrow) and the proximal of the feeding vessel (arrowhead) after coil embolization
Clinical characteristics of ruptured pulmonary artery pseudoaneurysm
To identify the risk factors for rupture of PAP, we compared the clinical features between ruptured and unruptured patients. The clinical characteristics and hemodynamic features of the two groups are summarized in Table 4 . No significant differences were observed between the two groups across gender, age, etiology, and distribution. Compared to the non-rupture group, the rupture group had a significantly higher proportion of massive hemoptysis (57.1% vs. 6.9%, p < 0.001), larger pseudoaneurysm diameter (8.1 ± 3.2 mm vs. 6.0 ± 2.3 mm, p = 0.012), higher incidence of pulmonary cavitation (76.2% vs. 44.8%, p = 0.027), and larger cavitation diameters (32.9 ± 18.8 mm vs. 15.7 ± 8.4 mm, p = 0.005). The mean pulmonary artery pressure (mPAP) in the ruptured group was also significantly higher than that in the unruptured group (23.9 ± 7.4 mmHg vs. 19.2 ± 5.0 mmHg, p = 0.011). Meanwhile, there was no statistical significance in the other hemodynamic parameters.
Treatment and outcome
Endovascular treatment was conducted in all patients with PAP rupture. As shown in Table 2 . Coil embolization was performed in 20 cases (95.2%), including pseudoaneurysm sac embolization in 13 cases (61.9%), pseudoaneurysm neck embolization in 1 case (4.8%), feeding vessel embolization in 10 cases (47.6%). One PAP was excluded with covered stents. No patient underwent surgical resection. The outcome and complication of patients with PAP rupture are listed in Table 5 . During the operation, one patient experienced stress-induced hypertension, and another one sustained a pulmonary artery injury. One patient suffered massive hemoptysis due to rupture of PAP during pulmonary angiography, and the hemoptysis stopped after immediate embolization. After the operation, fever, chest tightness, and chest pain were complained by patients with interventional treatment. All of the complications resolved spontaneously or following symptomatic treatment. None of the patients had pulmonary infarction. The technical and clinical success rate was 100% and 96.0%, respectively. One patient died of massive hemoptysis during hospitalization.
Of the patients received intravascular intervention for patients with PAP rupture, 17 patients completed one-year follow-up. One patient died of heart failure. Meanwhile, five patients had recurrences of hemoptysis, of which four occurred within 6 months.
This study described the clinical and imaging features of patients with hemoptysis and PAP, and further investigated the risk factors for rupture of PAP. The findings of this study indicated that massive hemoptysis, pseudoaneurysm diameter, cavitary lesions, and elevated mPAP were associated with an increased risk of PAP rupture. To our knowledge, this is the first study identifying risk factors for rupture of pseudoaneurysm. This study could assist clinicians in identifying high-risk patients of PAP rupture, offering insights into treatment strategies that could prevent delays in critical interventions.
The mechanism of PAP formation is vessel wall destruction and further replaced by granulomatous, neoplastic, or fibrotic tissue, resulting in the weakening of the arterial wall. Under sustained arterial pressure, blood dissects the injured artery and forms a perfused sac. Infection was the most common cause of acquired PAP in our patient population, which is consistent with previous studies [ 5 , 6 ]. Previous studies have reported that PAPs were often accompanied by cavitary lesions [ 3 , 4 , 7 ]. It revealed that PAP may have a predilection for pulmonary cavitation. In our study, PAPs were adjacent to pulmonary cavities in 29 patients (58%). Compared with the unruptured patients, the ruptured ones had a significantly higher proportion of pulmonary cavitation and the size of cavitary lesions was larger.
The underlying pathogenesis may be direct invasion of vessels by pathogenic bacteria and persistent damage by pulmonary lesions associated with tissue necrosis or inflammation. Cystic medial necrosis was observed in many perioperative samples of the vascular wall [ 15 ]. Inflammation has been considered as a central driving cause in the development of arterial aneurysm. Studies have demonstrated that Chlamydia pneumonia is detected in AAA with infiltration of inflammatory cells including macrophages, lymphocytes, and plasma cells in the aortic walls [ 16 , 17 , 18 ]. In terms of lung infection, patients with tuberculosis, necrotizing pneumonia, and suppurative bacterial and fungal infections were more likely to have PAP [ 19 ]. The common causative organisms of mycotic PAP were Staphylococcus and Streptococcus, especially in patients with infective endocarditis [ 20 , 21 ]. Of note, the vascular wall in the pulmonary circulation was destructed with the formation of PAP through hematogenous dissemination or direct spread from the pulmonary infectious focus. These patients often had a history of intravenous drug abuse and presented with fever, bacteremia, and massive hemoptysis, requiring intravascular interventional therapy [ 22 ]. Therefore, it is reasonable to infer that pulmonary cavities may be associated with the formation and rupture of PAP.
The degeneration of the pathological structure is not sufficient to produce an abnormal balloon shape. The formation and rupture of this abnormal structure are also influenced by intravascular hemodynamic effects in addition to the weakened arterial wall. In an observational study about a cohort of patients with pulmonary hypertension, the incidence of pulmonary artery aneurysm was about 38%, especially in patients with long disease duration [ 23 ]. In patients with hemoptysis due to PAP rupture, especially those with systemic-pulmonary shunts, pulmonary artery pressure is maintained between 35 and 69 mmHg [ 4 ]. Our data indicated that PAP in the ruptured group exhibited larger diameter and higher mPAP in comparison to the unruptured group. Similar to AAA, vessel wall tension escalates with both diameter and transmural pressure [ 24 ]. Arterial wall tension is directly proportional to both pressure and the radius of the diseased vessel while inversely correlated with arterial wall thickness according to the Laplace’s law. Rupture occurs when stress induced by blood flow exceeds the limit of wall tissue strength. Thus, risk of rupture in the PAP is closely associated with both size and pressure.
There are no guidelines for the indication of treatment and the best therapeutic approach. The main treatment for PAP were surgery and intravascular intervention. Surgical treatments such as lobectomy or aneurysmectomy were associated with high mortality [ 25 ]. Endovascular coil embolization and stent placement are currently preferred due to less invasive and fewer complications [ 26 , 27 ]. The selection of embolization material depends on the location, size, and classification of PAP. Coil embolization may be an effective choice for preserving distal pulmonary artery perfusion and avoiding lung perfusion injury. The stent is generally recommended for fusiform or lobar arterial pseudoaneurysm in the pulmonary. Of the current study, most of the patients received coil embolization and only one PAP located in the lobar branch was excluded with a covered stent. Due to vulnerability to rupture of PAP, the operator should be alert to sudden rupture during the operation [ 28 ]. In our series, one rupture occurred during pulmonary angiography. The possible reason might be a transient increase in pulmonary perfusion and local pressure with contrast agent injection, or direct damage to microcatheters and microwires during the procedure. In addition, some infectious PAP is curable. The conservative treatment with intravenous antibiotics alone has been documented to be successful in patients with small and stable aneurysms [ 29 ].
We acknowledge several limitations of our study. First, although our study cohort was relatively large compared to the previous studies, we still did not include all causes of PAP, such as endocarditis due to the limited cases. Furthermore, the natural history of PAP has not yet been extensively studied and remains largely unknown. Experts evaluated the cause of PAP based on the history and imaging of patients. Thus, its accuracy and conclusiveness may be limited. Additionally, longer-term follow-up studies are crucial for evaluating the extended prognosis of patients with PAP and hemoptysis.
In conclusion, we found that PAP patients with rupture had a significantly higher proportion of massive hemoptysis and pulmonary cavitation, larger pseudoaneurysm and cavitation diameter, as well as higher mPAP. Collectively, we have characterized the clinical features of PAPs and explored risk factors of rupture, providing novel insights into the early identification of PAPs with high risk of rupture.
Data availability
The data used and analyzed in the study are available from the corresponding author on reasonable request.
Abbreviations
- Pulmonary artery pseudoaneurysm
Abdominal aortic aneurysm
Cardiac output
Cardiac index
Mean pulmonary artery pressure
Pulmonary artery wedge pressure
Pulmonary vascular resistance
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Acknowledgements
The authors thank all the patients who participated in this study.
This work was supported by National High Level Hospital Clinical Research Funding (2022-NHLHCRF-LX-01-0203), CAMS Innovation Fund for Medical Sciences (No. 2021-I2M-1-049,2021-I2M-1-061), China Postdoctoral Science Foundation (2023TQ0383) and Wuhan Medical Research project (WX20D85).
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Min Liu, Jixiang Liu and Wei Yu contributed equally to this work.
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National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship Hospital, No 2, East Yinghua Road, 100029, Beijing, China
Min Liu, Jixiang Liu & Zhenguo Zhai
Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Jianghan University, No.168 Hongkong Road, 430000, Wuhan, Hubei, China
Wei Yu, Xiaoyan Gao, Shi Chen, Wei Qin, Ziyang Zhu, Chenghong Li & Fajiu Li
Institute of Pulmonary Vascular Diseases, Jianghan University, No.168 Hongkong Road, 430000, Wuhan, Hubei, China
Chenghong Li
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ML, JL conceived the project, collected the data, drafted and revised the manuscript. WY, XG, SC, WQ, ZZ collected patient information, provided the figures and interpreted data. CL, FL, ZZ reviewed and revised the final draft of the manuscript. All the authors have read, discussed and approved the manuscript.
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Correspondence to Fajiu Li or Zhenguo Zhai .
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Liu, M., Liu, J., Yu, W. et al. Clinical and radiological features associated with rupture of pulmonary artery pseudoaneurysm: a retrospective study. BMC Pulm Med 24 , 417 (2024). https://doi.org/10.1186/s12890-024-03225-0
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DOI : https://doi.org/10.1186/s12890-024-03225-0
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Scrub typhus with hemorrhagic stroke: a case report
Om prakash bhatta.
1 Department of Internal Medicine, Nova Hospital, Dhangadhi, Nepal
Sabita Chand
Hemant chand, prashant bhetwal.
2 Panchkhal PHC, Kavrepalanchowk, Nepal
Sachin Awasthi
3 Department of Emergency Medicine, Yashoda Hospital, Banke, Nepal
Aruna Acharya
4 Department of Community Medicine, Nepalgunj Medical College, Banke, Nepal
Ram Chandra Poudel
Associated data.
The authors declare that data supporting the findings of this study are available within the article.
Scrub typhus, caused by Orientia tsutsugamushi , rarely leads to central nervous system involvement. Although intracerebral bleeding is rare due to endemicity and a significant proportion of underdiagnoses, it should be considered a noteworthy differential diagnosis in endemic regions in patients with relevant history and clinical findings.
Case presentation
We present the case of a 40-year-old Nepali woman who visited the emergency department with complaints of left-sided weakness for 6 hours and an acute febrile illness with an eschar for 7 days and was diagnosed with scrub typhus by immunoglobulin M enzyme-linked immunosorbent assay of the serum. Imaging revealed a right-sided frontotemporal hematoma, and further examination revealed pulmonary edema with multiple organ dysfunction syndrome. The patient was mechanically ventilated and was treated with antibiotics, steroids, vasopressors, and antipyretics. However, the hematoma was treated conservatively, with ongoing neurological recovery at the 6-month follow-up.
Although neurological complications and intracranial hemorrhage are uncommon, physicians must be cautious when making differential diagnoses and initiating appropriate therapies to avoid serious or fatal complications.
Scrub typhus, also known as tsutsugamushi disease, is a life-threatening zoonotic disease caused by an obligate intracellular Gram-negative bacillus, Orientia tsutsugamushi , that commonly affects farmers in endemic regions in and around the monsoon [ 1 ]. It can present with nonspecific illnesses such as fever, headache, myalgia, nausea, vomiting, dizziness, maculopapular rashes, or severe multiorgan dysfunction involving almost any organ system [ 2 , 3 ].
It is estimated that scrub typhus threatens one billion people globally and leads to at least one million clinical cases annually in the Asia–Pacific region [ 4 ]. It is an endemic infection in Nepal with a seroprevalence of 12.2% in patients with acute febrile illness; however, some studies report even higher prevalence rates, as high as 40.3% [ 5 , 6 ]. However, nationwide data on the genetic diversity of this pathogen in Nepal are lacking.
There is a paucity of literature on the neurological manifestations of scrub typhus. A literature search on intracranial hemorrhage (ICH) associated with scrub typhus showed it to be quite rare. We present the case of a 40-year-old Nepali woman with fever diagnosed with scrub typhus who developed intracranial hemorrhage. This case highlights the need for heightened vigilance among clinicians and greater scrutiny of patients with multisystemic involvement, focusing on tropical infections in endemic regions.
A 40-year-old Nepali female from the far western region of Nepal presented to our emergency department with sudden onset weakness in the left side of her body for the last six hours. She had difficulty speaking for the same duration. However, the patient had no history of loss of consciousness or comprehension. She developed a fever 7 days prior, which was moderate to high grade, continuous, and without chills or rigor. It was initially associated with mild headaches, multiple episodes of nonbilious vomiting, and generalized body weakness but not with vision difficulty, altered mentation, cough, chest pain, abdominal pain, or burning urine. Her symptoms did not resolve even after 4 days of over-the-counter medication. For the last 3 days, she had shortness of breath and cough with occasional mucoid expectoration.
On initial assessment, the patient was confused and anxious with a Glasgow coma scale (GCS) of E4 V4 M6 (14/15), a temperature of 102 °F, blood pressure (BP) of 80/50 mmHg, heart rate of 123 beats per minute, and oxygen saturation (SPO 2 ) of 78% at room air. She was pale and icteric with bilateral chest crepitations. Head-to-toe examination revealed a rash with a brownish-black scab in the right buttock region (Fig. 1 ). The pupils were reactive to light, bilateral plantar responses were normal, and there was no neck rigidity. The past medical and surgical history was unremarkable.
Eschar present in the right buttock region (white arrow)
A noncontrast computed tomography (CT) scan of the head revealed acute parenchymal hemorrhage in the right frontal lobe with vasogenic edema and mild mass effects (Fig. 2 ). Serological tests were performed for dengue, leptospirosis, and Brucella , which were reported to be negative. Tuberculosis was excluded based on negative sputum acid-fast bacilli (AFB) staining and sputum culture results, and human immunodeficiency (HIV) serology was negative. Similarly, thick and thin smears for malaria and polymerase chain reaction (PCR) for coronavirus disease 2019 (COVID-19) were also negative. However, the scrub typhus test was positive for IgM ELISA (Scrub Typhus Detect™ IgM ELISA Kit by InBios). Ultrasonography (USG) of the abdomen and pelvis revealed diffuse gallbladder thickening, borderline splenomegaly, and pleural effusion (right > left). Chest radiography at admission revealed bilateral pulmonary infiltrates and features suggestive of pulmonary edema (Fig. 3 ).
Noncontrast computed tomography head revealed an acute parenchymal hemorrhage in the right frontal lobe (white arrows) with vasogenic edema and mild mass effects
Chest radiograph revealed bilateral pulmonary infiltrates (white arrows)
Laboratory investigations revealed a total leukocyte count (TLC) of 13,200 cells/μL, neutrophils (N) 88%, lymphocytes (L) 5%, monocytes (M) 4%, hemoglobin 10 g/dL, platelets 660,000 cells/μL, random blood sugar 71.2 mg/dL, blood urea 80 mg/dL, serum creatinine 1.7 mg/dL, and serum sodium 134.5 mg/dL. A liver function test showed bilirubin total 6.2 mg/dL and direct 2.7 mg/dL, alanine transaminase 72.3 units/L, aspartate transaminase 228.6 units/L, and alkaline phosphatase 619.9 IU/L. Arterial blood gas (ABG) results were as follows: pH 7.348, paO 2 96 mmHg, paCO 2 29.5 mmHg, bicarbonate 17.3 mmol/L, and lactate 2.02 mmol/L. The blood cultures were sterile. The detailed laboratory investigations are presented in Table 1 .
Table 1
Summary of laboratory investigations during hospital stay and their values
Test | Test of the timing | Value | Remarks |
---|---|---|---|
Arterial blood gas (ABG) | At admission | pH 7.26, pCO 31 mmHg, HCO 15.8 mmol/L, lactate 5.54 mmol/L | |
48 hours after admission | pH 7.53, pCO 24 mmHg, HCO 23.3 mmol/L, lactate 1.12 mmol/L | ||
Liver function test (LFT) | At admission | Bilirubin; total 6.2 mg/dL and direct 2.7 mg/dL alanine transaminase (ALT) 72.3 units/L; aspartate transaminase (AST) 228.6 units/L; alkaline phosphatase (ALP) 619.9 IU/L | |
Complete blood count (CBC) | At admission | Hb 10 g/dL, TLC 13,200 cells/μL N88% L5%, platelets 460,000 cells/μL | |
At discharge | Hb 10 gm%, TLC 11,300/cells/μL N86% L8%, platelets 380,000 cells/μL | ||
Renal function test (RFT) | At admission | Na 134.5 mg/dL, K 3.30 mg/dL, urea 80 mg/dL, creatinine 1.7 mg/dl | |
At discharge | Na 142 mg/dL, K 4.50 mg/dL, urea 46 mg/dL, creatinine 0.8 mg/dL | ||
PT/INR | At admission | 17 seconds/1.38 | |
Erythrocyte sedimentation rate (ESR)/ c-reactive protein (CRP) | At admission | ESR: 55 mm per hour/CRP: 125 mg/L |
ABG arterial blood gas, CBC complete blood count, RFT renal function test, PT/INR prothrombin time/international normalized ratio, Hb hemoglobin, TLC total leukocyte count, Na sodium, K potassium, ESR erythrocyte sedimentation rate, CRP c-reactive protein
Based on brain imaging and serological findings, the working diagnosis was scrub typhus with multiple organ dysfunction syndrome and intracranial hemorrhage. The primary differential diagnoses were dengue fever, falciparum malaria, leptospirosis, and COVID-19.
After the initial evaluation, the patient was transferred to the intensive care unit (ICU) and managed with inotropic support, antipyretics, antibiotics (Piperacillin–tazobactam injection and doxycycline injection), nebulization, and other supportive measures. Initially, oxygen saturation was maintained at 10 L/minute via a nonrebreather face mask (NRBFM). However, her condition deteriorated within an hour, and her oxygen requirement increased, requiring 15 L/minute of oxygen via the NRBFM. Diuretics (torsemide injection) were administered to treat the pulmonary edema, and inotropic support was continued. The patient was mechanically ventilated on the second day of admission because of respiratory distress and a fall in GCS score (during intubation, E3V2M5). She was scheduled for conservative management of the ICH after neurosurgical consultation.
Following 3 days of mechanical ventilation and conservative treatment for ICH, she was extubated on the third day with good recovery of her respiratory function, resolution of multiorgan dysfunction (MODS), and maintenance of saturation of 92–94% with oxygen support of 2–3 L/minute via nasal prongs.
Her neurological status after extubation was good with residual left hemiparesis. The patient began maintaining saturation in room air on the sixth day of admission, and was discharged on the tenth day after being advised to seek physiotherapy. During her recent follow-up after 6 months, she recovered well, with a recent neurological examination showing residual left hemiparesis.
Scrub typhus is transmitted by the bite of the “chigger” larva of the trombiculid mite, which is both a reservoir and vector of the disease [ 3 ]. The site of the chigger bite develops localized necrosis of the tissue, producing a black scab called “eschar,” which is pathognomonic of the disease but only identified in approximately one in five cases [ 7 ].
Scrub typhus may present with a wide range of clinical features, ranging from acute febrile illness to MODS. Although relatively uncommon, neurological involvement can occur in approximately 20% of patients, with reported manifestations including aseptic meningitis, meningoencephalitis, acute hearing loss, cerebral infarction, polyneuropathy, transverse myelitis, isolated cranial nerve palsy, Landry–Guillain‒Barré syndrome (LGBS), and posterior reversible encephalopathy syndrome (PRES) [ 3 , 4 ].
Although there is evidence that the blood‒brain barrier may be directly breached by microvascular endothelial damage or by bacteria migrating across cells, either independently or as a result of being engulfed by macrophages, the precise mechanism remains unclear [ 8 ]. Entry into the CNS is followed by the activation of transcription factors, such as nuclear factor-kappa B, which induces inflammation and is responsible for various neurological sequelae [ 9 ]. During the illness, hemostatic and fibrinolytic changes occur [ 8 ]. The bacterium is distributed throughout the body via blood and lymphatics, inducing a vasculitis-type reaction with endothelial injury, perivascular infiltration of leukocytes, increased vascular permeability, and microvascular thrombosis, resulting in end-organ damage [ 9 ].
Suspicion of CNS involvement stems from a history of headache, vomiting, altered sensorium, abnormal body movements, dizziness, hearing loss, and urine and stool incontinence. However, systemic manifestations are more frequent in patients with CNS involvement, leading to diagnostic dilemmas [ 3 , 7 ].
We diagnosed scrub typhus using IgM ELISA (Scrub Typhus Detect™ IgM ELISA Kit), which has a sensitivity of 91.5% and specificity of 92.4% [ 10 ]. PCR is widely recommended as a confirmatory test (sensitivity of 90% and specificity of 100%); however, it was unavailable in our setting [ 11 ]. The presence of bacteria in the cerebrospinal fluid (CSF) can be demonstrated using nested PCR [ 12 ].
Routine blood tests and other specialized investigations can also be performed depending on systemic involvement. Although there are no specific neuroradiological features pathognomonic of scrub typhus, supportive imaging investigations include computed tomography (CT), magnetic resonance imaging (MRI), and CT angiography to diagnose and confirm intracranial hemorrhage [ 7 , 13 ].
This patient with an acute febrile illness had features suggestive of stroke. Other common causes of stroke were excluded from the history, as she was not on any anticoagulants or other medications and had no other comorbidities or family history of stroke. Additionally, other infectious causes of stroke, such as HIV, HSV, tuberculosis, dengue fever, falciparum malaria, and leptospirosis, were excluded [ 7 ].
The median mortality rate of untreated scrub typhus is approximately 6%, depending on organ involvement and age of the patient [ 14 ]. Doxycycline is the antibiotic of choice and shows an excellent response within 48 hours of administration, when aided by supportive measures. In pregnancy, doxycycline is contraindicated, and azithromycin is used [ 7 , 15 ].
Concurrently, patients require management of hemorrhagic stroke and neurosurgical evaluation and management to assess mass effects. Blood pressure control is crucial, and antiepileptic drugs may be used for seizure prophylaxis. Rehabilitation and long-term care may be needed to address deficits and aid recovery once a patient’s condition stabilizes [ 3 , 16 ].
Chung et al. reported three patients diagnosed with scrub typhus through serology and PCR who experienced delayed administration of effective antibiotics after the appearance of symptoms and presented with a cerebrovascular accident in the late acute phase, resulting in fatality [ 12 ].
Clinicians should be aware of the diverse manifestations and severe complications of scrub typhus, particularly in and around the monsoon in endemic regions. Although rare, it may present with life-threatening neurological manifestations that can mimic other infectious pathologies. A precise history, thorough clinical examination, and necessary investigations help reach a final diagnosis and provide optimal management. Timely management with antimicrobial agents leads to a good response with little residual neurological dysfunction.
Acknowledgements
The authors wish to acknowledge the patient included in this report.
Abbreviations
CNS | Central nervous system |
CT | Computed tomography |
MRI | Magnetic resonance imaging |
MODS | Multiorgan dysfunction |
ABG | Arterial blood gas |
GCS | Glasgow coma scale |
LGBS | Landry–Guillain‒Barré syndrome |
PRES | Posterior reversible encephalopathy syndrome |
IgM | Immunoglobulin M |
ELISA | Enzyme-linked immunosorbent assay |
Author contributions
RCP, OPB, SC, and HC: study concept, data collection, and management of the patient. OPB, SC, PB, AA, and SA: writing—original draft preparation and editing. RCP: senior author and manuscript reviewer. All authors critically reviewed, revised, and contributed to the final article. All the authors have read and approved the final manuscript.
Availability of data and materials
Declarations.
Ethical approval was exempt at the authors’ institution. The patient agreed to participate in this study. Informed consent was obtained from the patient prior to the study.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
All authors certify that they have no competing interests to declare that are relevant to the content of this article.
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- Case report
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- Published: 26 August 2024
Successful conservative management of advanced pyogenic sternoclavicular joint arthritis with osteomyelitis and pulmonary infiltration: a case report
- Takahito Sugihara ORCID: orcid.org/0009-0008-5351-7448 1 ,
- Yoshifumi Sano 1 ,
- Takashi Ueki 1 ,
- Takao Ishimura 1 ,
- Masashi Takeda 1 ,
- Yosuke Kiriyama 1 ,
- Yu Mori 1 ,
- Nobuhiko Sakao 1 ,
- Shinji Otani 1 &
- Hironori Izutani 1
Journal of Medical Case Reports volume 18 , Article number: 394 ( 2024 ) Cite this article
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Metrics details
Sternoclavicular joint arthritis is a rare condition that poses considerable diagnostic and therapeutic challenges, leading to severe complications and a high mortality rate. Although surgical interventions are often considered necessary for advanced cases, some reports have suggested that conservative management with antibiotic therapy can be effective in certain cases. However, to our knowledge, there are no reports of successful conservative treatment in cases exhibiting aggressive spread. This report highlights a case of advanced sternoclavicular joint arthritis with bone destruction and pulmonary infiltration, successfully treated conservatively with outpatient antibiotic therapy.
Case presentation
A 58-year-old Japanese male presented with a 1-month history of left-sided shoulder pain. Contrast-enhanced computed tomography showed abscess formation and clavicular bone destruction, with infiltrative shadows suggesting lung involvement. The diagnosis of sternoclavicular joint arthritis was made, and outpatient oral antibiotic therapy was initiated. The patient exhibited a marked reduction in inflammatory marker levels and symptoms, and antibiotic therapy was discontinued after 3 weeks, with no recurrence observed at a 4-month follow-up.
Conclusions
This case highlights that conservative management with antibiotics can be effective for treating advanced sternoclavicular joint arthritis, emphasizing the need for individualized management and further research into non-surgical treatment options.
Peer Review reports
Sternoclavicular joint (SCJ) arthritis is a rare condition requiring prompt and accurate diagnosis and treatment, as delayed diagnosis can result in serious complications, such as osteomyelitis, mediastinitis, and sepsis, which are associated with a high mortality rate of 10% [ 1 ]. The diagnostic criteria for SCJ arthritis are lacking [ 2 ], and its diagnosis is typically based on a thorough history, physical examination, laboratory workup, imaging findings, and arthrocentesis. Although surgical procedures are considered inevitable, conservative management is effective in some cases [ 3 , 4 ]. However, previous reports were limited to patients with mild inflammation. Herein, we report a case of successful conservative outpatient treatment of advanced SCJ arthritis with bone destruction and pulmonary infiltration.
A 58-year-old Japanese male with a history of chronic sinusitis, hyperuricemia, and depression presented with left-sided shoulder pain persisting for 1 month. He was not a smoker and only drank socially. He had no remarkable family medical history, and he worked in the hospitality industry. He had no history of medication use. Computed tomography (CT) performed before presentation revealed a low-density area around the left SCJ, prompting referral to our institution.
Upon examination, the patient was hemodynamically stable, with a body temperature of 36.9 ℃, blood pressure of 133/86 mmHg, and a pulse rate of 78 beats per minute (bpm). Physical examination revealed mild swelling and tenderness around the left SCJ. In addition, no skin breakdown or indwelling prosthetic devices including intravascular catheters and cardiac devices were present. No evidence of dental caries, swollen tonsils, or significant limitation of left-shoulder movement was observed. Laboratory findings revealed a white blood cell (WBC) count of 11,300 cells/mm 3 and a C-reactive protein (CRP) level of 5.16 mg/dL (Table 1 ). Moreover, the levels of tumor markers, including carcinoembryonic antigen, cytokeratin 19 fragment, and squamous cell carcinoma antigen, were within normal ranges.
Contrast-enhanced CT revealed a low-density area extending from the anterior-neck muscles to the posterior sternal region and left clavicle with mild peripheral enhancement, indicating abscess formation, and clavicular bone destruction (Fig. 1 a, b). Furthermore, infiltrative shadows in the left lung apex suggested the spread of inflammation (Fig. 1 c). Neck ultrasonography revealed a hypoechoic area within the muscles of the anterior neck, suggestive of abscess formation.
Contrast-enhanced computed tomography findings at the initial presentation. a Neck abscess (yellow circle), b soft-tissue swelling around the left sternoclavicular joint with clavicular bone destruction (yellow circle), and c infiltrative shadows in the left lung apex suggesting the spread of inflammation to the lung (red circle)
The patient was diagnosed with SCJ arthritis, and oral sulbactam/ampicillin (1125 mg/day) was initiated in an outpatient setting to provide coverage against anaerobic germs. Additionally, ultrasound-guided aspiration of the cervical abscess was performed, and methicillin-sensitive Staphylococcus aureus was detected in the aspirate culture, supporting the continuation of oral antibiotics. Cellular cytology revealed no malignant findings. Weekly follow-ups were conducted, including blood tests, CT, and neck ultrasonography. A total of 1 week after starting treatment, pain, swelling, and inflammatory marker values such as WBC counts and CRP levels showed improvement on examination. The antibiotic was switched to oral levofloxacin (500 mg/day), which showed higher sensitivity on blood culture tests.
A total of 3 weeks after treatment initiation, the inflammatory marker levels normalized, and antibiotic therapy was discontinued (Fig. 2 ). No symptom recurrence was observed at the 4-month follow-up after completing antibiotic treatment (Fig. 3 ). Additionally, the patient had no difficulty with upper limb movement and experienced no residual swelling or pain.
Therapeutic course of sternoclavicular joint arthritis. CRP, C-reactive protein; LVFX, levofloxacin; SBT/ABPC, sulbactam/ampicillin; WBC, white blood cell
Computed tomography 4 months after completing antibiotic treatment. a Complete resolution of the neck abscess and significant improvement in b the soft-tissue swelling around the left sternoclavicular joint and c lung inflammation
Discussion and conclusions
This report presents new findings that conservative treatment with antibiotics and other measures can lead to improvement even in cases of SCJ arthritis with abscess formation and bone destruction, which were previously thought to necessitate surgical intervention. The basis of this approach lies in the advancements in medicine, including antibiotics and other drugs, and the idea that these advancements make new methods, rather than traditional ones, sometimes effective.
The estimated prevalence of SCJ infections is less than 1% of all septic arthritis cases [ 5 ]. Ross et al . [ 6 ] reported 180 cases of SCJ infections, almost half of which were caused by S. aureus , followed by Pseudomonas aeruginosa (10%), and Brucella melitensis (7%). Clinical symptoms included pain around the SCJ (78%), fever (65%), and shoulder-joint pain (24%). Risk factors included frequent use of intravenous drugs (21%), spread of infection from a distant site (15%), diabetes (13%), trauma (12%), and central-venous-line infection (9%). However, 23% of cases occurred in healthy individuals without any identified risk factors [ 6 ]. Although standard diagnostic criteria have not been established, CT-guided arthrocentesis yields a positive culture in over 50% of cases [ 7 ].
Conventionally, SCJ arthritis management includes surgery, ranging from simple incision and drainage to extensive debridement and reconstruction [ 8 , 9 ]. Surgical resection combined with muscle transposition provides effective long-term outcomes. Joint resection combined with intravenous antibiotics effectively and expeditiously eliminates the disease. In particular, en bloc joint resection and bone and soft-tissue debridement are indicated in the case of extensive bony destruction, chest-wall phlegmon or abscess, retrosternal abscess, mediastinitis, or pleural extension [ 10 ]. Although surgical intervention combined with targeted antibiotic therapy is the mainstay of treatment, several cases of SCJ arthritis without life-threatening complications have been successfully treated with antibiotic therapy alone [ 3 , 6 , 11 ]. Surgical intervention is associated with morbidity risks not encountered with antibiotic therapy. Factors such as adverse reactions to anesthesia, postsurgical infections, and the potential need for additional surgeries must be carefully considered before surgical treatment. Furthermore, the instability of the SCJ induced by surgical intervention may lead to impairments in upper limb elevation [ 11 ]. Notably, for patients without severe signs of osteomyelitis or systemic infection, treatment with antibiotics alone should be considered a viable option [ 2 ]. Successful medical management has been reported even in patients with clavicular osteomyelitis. For example, a patient showing early signs of osteomyelitis was successfully treated with a 4-week course of intravenous antibiotics [ 12 ].
In our patient, outpatient antibiotic therapy was selected on the basis of the mild elevation of inflammatory marker levels and absence of high fever despite evidence of inflammatory spread. This case emphasizes substantial improvement in antibiotics and advancements in diagnostic equipment and technologies.
In conclusion, we encountered a rare case of SCJ arthritis with pulmonary extension and osteomyelitis that was successfully treated with antibiotic therapy in the outpatient setting. This report demonstrates that conservative treatment may be effective even in appropriately selected cases of advanced SCJ arthritis.
Availability of data and materials
Further information about this study is available by contacting the corresponding author.
Abbreviations
C-reactive protein
Computed tomography
Sternoclavicular joint
White blood cell
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We thank Editage ( www.editage.jp ) for English language editing.
This research did not receive any specific grants from funding agencies in the public, commercial, or not-for-profit sectors.
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Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, 454, Shitsukawa, Toon, Ehime, 791-0204, Japan
Takahito Sugihara, Yoshifumi Sano, Takashi Ueki, Takao Ishimura, Masashi Takeda, Yosuke Kiriyama, Yu Mori, Nobuhiko Sakao, Shinji Otani & Hironori Izutani
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Conceptualization: T.S. and Y.S.; Investigation: T.S. and Y.S.; Writing—original draft: T.S.; Writing—review and editing: All authors.
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Correspondence to Takahito Sugihara .
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Sugihara, T., Sano, Y., Ueki, T. et al. Successful conservative management of advanced pyogenic sternoclavicular joint arthritis with osteomyelitis and pulmonary infiltration: a case report. J Med Case Reports 18 , 394 (2024). https://doi.org/10.1186/s13256-024-04684-z
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Published : 26 August 2024
DOI : https://doi.org/10.1186/s13256-024-04684-z
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