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Research Technician

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The Haq Lab is looking for an enthusiastic and talented research technician to join our team at Dana-Farber Cancer Institute / Harvard Medical School. Our lab uses state-of-the-art molecular cellular and genetic approaches to study cancer therapy resistance, including immunotherapy (Gstalder et al, Cancer Discovery 2019) and targeted therapy (e.g., Montero et al, Nature Communications 2018). Some of our projects have involved the development of novel therapeutics to reverse resistance to existing therapies.

Our lab is part of the division of Molecular and Cellular Oncology, within the world-renowned Dana-Farber Cancer Institute, which offers a dynamic, multidisciplinary environment with close interaction with other basic and clinical scientists including the Broad Institute at Harvard and MIT. This is an ideal opportunity for an highly motivated and committed technician to make an important contribution to understanding melanoma biology. Details of our lab are at: https://haqlab.dana-farber.org .

Responsibilities

• Set up, adjust, calibrate, clean, maintain and troubleshoot equipment.
• Clean, maintain and prepare supplies and work areas and may be responsible for ordering of supplies. Collaborates with Purchasing and may be responsible for negotiating with vendors.
• Conduct standardized biological, microbiological or biochemical tests and laboratory analyses, including the collection of information and samples from organic substances, such as blood, drugs, and animals.
• Isolate, identify and prepare specimens for examination.
• Analyze experimental data and interpret results to write reports and summaries of findings, including grant preparation and presentations, and look for opportunities to co-author publications. May be expected to participate in formal and information presentations of results to staff. 
• Participate in grant application process and manuscript preparation as required.
• Maintains detailed notebook of all work-related activities.
• Monitors laboratory work to ensure compliance with Environmental Health and Safety information as well as the standard operation procedures specific to each laboratory.
• Expected to provide intellectual and interactive commitment to position by keeping up with appropriate literature and research publications.
• May be responsible for the development, modification and improvement of standard operating procedures.
• Uses computers, computer-interfaced equipment, robotics or high-technology applications to perform work duties.
• May be responsible for designing and executing advanced experiments and setting strategy. 
• May be responsible for the examination of animals and specimens to detect the presence of disease or other problems.
• May be responsible for monitoring laboratory budgets.

Qualifications

• Bachelor's Degree required with a major in biology or chemistry preferred. 
• Knowledge of information and techniques related to either biology, chemistry, or medicine is preferred.
• Must have excellent communication skills (written and verbal) and be able to work with a wide variety of faculty and staff.
• Ability to analyze information and use logic to address work-related issues and problems.
• Must have attention to detail and be thorough in completing work tasks.
• Ability to work within a team environment.

KNOWLEDGE, SKILLS AND ABILITIES REQUIRED:

At Dana-Farber Cancer Institute, we work every day to create an innovative, caring, and inclusive environment where every patient, family, and staff member feels they belong.  As relentless as we are in our mission to reduce the burden of cancer for all, we are equally committed to diversifying our faculty and staff.  Cancer knows no boundaries and when it comes to hiring the most dedicated and diverse professionals, neither do we. If working in this kind of organization inspires you, we encourage you to apply.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other characteristics protected by law.

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COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Clinical Research Coordinator

• Herbert Irving Comprehensive Cancer Center
• Columbia University Medical Center
• Opening on: Aug 20 2024
• Job Type: Officer of Administration
• Bargaining Unit:
• Regular/Temporary: Regular
• End Date if Temporary:
• Hours Per Week: 35
• Standard Work Schedule:
• Salary Range: $62,400 - $65,000

Position Summary

The Clinical Research Coordinator manages clinical trials conducted through the Clinical Protocol & Data Management Office. This position reports directly to the Clinical Research Manager of the specific disease site this incumbent is assigned to. The Clinical Research Coordinator manages clinical trials (including some regulatory and budget requirements) and assists in the coordination of tests/visits for patients, working with the study team to maximize work efficiency to gather all required data and relevant clinical information.

Subject to business needs, we may support flexible and hybrid work arrangements. Options will be discussed during the interview process.

Responsibilities

Responsibilities include, but are not limited to:

GENERAL STUDY MANAGEMENT

• Reviewing research protocols
• Assisting Principal Investigators in drafting budgets and submitting studies
• Interacting with the regulatory office to maintain regulatory documentation and administrative files for each protocol
• Under the supervision of the clinical research management office supervisor, the coordinator maintains procedures necessary for timely and complete data management and complies with required supervision tools such as work logs and regular meetings.
• The coordinator will also comply with necessary regulatory responsibilities

PATIENT MANAGEMENT

• Coordinates study enrollment, protocol treatment, and follow-up care for patients participating in clinical trials in conjunction with the clinical research nurse, research pharmacy, treatment center, and other study staff
• Working with the research nurse, treating physicians, and Principal Investigators to confirm that each patient meets eligibility criteria specified for protocols and enrollment into clinical trials
• Communicating with various departments, physicians, labs, outside hospitals, and all members of the clinical team to ensure accuracy, timely retrieval of data, and confirm the appropriateness and timeliness of tests
• Collecting follow-up data on patient post-treatment as required by the protocol and submit monthly reports to the clinical protocol office, tracking patient enrollment and accounts/payments for sponsored protocols
• Completes timely research billing review
• Maintains and updates sponsor-related, university and department databases/logs

DATA MANAGEMENT

• Handling data management requirements for each patient enrolled
• Abstracts, assembles, and organizes clinical research data
• Coordinator performs other related duties and participates in special projects as assigned

Minimum Qualifications

• Bachelor’s Degree or equivalent in education, training, and experience.

Preferred Qualifications

• Experience in a clinical research setting with knowledge of HIPAA and GCP.

Other Requirements

• Excellent interpersonal and organizational skills.
• Computer Skills: proficiency with MS Word programs and familiarity with Mac and PC platforms.

Equal Opportunity Employer / Disability / Veteran

Columbia University is committed to the hiring of qualified local residents.

Commitment to Diversity 

Columbia university is dedicated to increasing diversity in its workforce, its student body, and its educational programs. achieving continued academic excellence and creating a vibrant university community require nothing less. in fulfilling its mission to advance diversity at the university, columbia seeks to hire, retain, and promote exceptionally talented individuals from diverse backgrounds.  , share this job.

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Ritchie School Professor Dali Sun Talks His Career and Groundbreaking Pancreatic Research

Owyn cooper.

Communications and Events Specialist

[email protected]

303-871-4218

Biosensing Engineering Professor discusses his groundbreaking engineering research with cancer through collaboration across many STEM fields

Dr. Dali Sun, professor in biosensor technology, MATLAB, instrumentation and data acquisition at the Ritchie School of Engineering and Computer Science, recently published a research paper titled “ Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells .” 

As explained in the paper’s abstract, “Pancreatic adenocarcinoma (PDAC) is one of the most deadly   cancers, characterized by extremely limited therapeutic options and a poor prognosis, as it is often diagnosed during late disease stages. Through proteomics analysis of extracellular vesicles, we discovered an imbalanced distribution of amino acids secreted by PDAC tumor cells.” 

With Dr. Sun’s focus in biosensing technology and bioinstrumentation, he was excited to put his engineering research to work in advancing clinical tools. 

“Because we are engineers, we do tools to help clinicians or to help researchers to study disease,” said Dr. Sun. “While we study these tools, we found some phenomena that can be divided into three domains or detection algorithms. We then dive into those new masters we developed and try to find a solution.”

As part of the endeavor to find a cure for cancer, the research process also works to ensure that the patient is not suffering during the healing process. “In order to decrease the suffering from the patient, we want to find a solution that does not introduce a lot of side effects,” Dr. Sun said.

In a Q+A with the Ritchie School, he delved into his background and experience in biosensing engineering. 

1. How did you get into biosensing engineering?

I got into biosensing engineering because of my fascination with the intersection of biology and technology. With a multidisciplinary background in Biology, Computer Science, Electrical Engineering, and Biomedical Engineering, I have been able to understand how engineering principles can solve complex biological problems. This unique blend of education and industry experience inspired me to pursue graduate studies focused on biosensing technologies. 

I wanted to develop innovative solutions for detecting and monitoring various biological processes. The potential to make a significant impact on healthcare by creating devices that enable early disease detection and real-time monitoring truly solidified my passion for this field.

2. What inspired you to study and research pancreatic cancer treatment?

One of the inspirations is  the high mortality rate and the lack of effective therapies for this aggressive disease. Pancreatic cancer often presents at an advanced stage, making it difficult to treat. Another source of inspiration for me is that this is the first cancer where I have observed something remarkable through my multidisciplinary approach—an insight that could aid in the detection of this cancer. 

In scientific research, both inspiration and luck play crucial roles. This initial observation, combined with the urgent need for new therapeutic strategies, has driven me to focus my research in this area. Witnessing many patients suffer from severe side effects, and my personal experiences with loved ones affected by cancer, has only heightened my commitment to finding innovative solutions that can improve patient outcomes and quality of life.

3. With pancreatic cancer treatment, how did the multidisciplinary approach come to be?

Our multidisciplinary approach to treating pancreatic cancer arose from recognizing that addressing this complex disease requires expertise from various fields. Initially, our strategy was inspired by data analysis methods grounded in my computer science background. Based on proteomics result, we processed data and found promising leads. To validate these leads, we employed biochemistry and bioengineering techniques, conducting in vitro assays and confirming the concept in vivo with mice. 

By merging the strengths of bioengineering, molecular biology, and clinical research, we have been able to develop comprehensive treatment strategies. Collaboration with experts in these fields has allowed us to design novel therapeutic agents and gain a deeper understanding of the disease's underlying mechanisms. This holistic approach has been pivotal in advancing our research and moving us closer to effective treatments.

4. What is a rewarding aspect of teaching engineering to Ritchie School students?

My teaching philosophy centers on connecting real-world problems to what students are learning. It's incredibly rewarding to see students applying the knowledge from my class directly to their job hunting and future careers. While some engineering concepts can be quite abstract, I strive to make them as easy to understand as possible. 

I firmly believe that no knowledge is too difficult to learn. In my class, students don’t need to know everything to start learning. As a proponent of multidisciplinary education, I encourage students not to be afraid of exploring new fields.

Regardless of your background, come to my class and let me guide you through the learning process. One of the most fulfilling aspects of teaching engineering at Ritchie School is witnessing students grow and develop as they master complex concepts and apply them creatively. Seeing students develop critical thinking skills, innovate, and solve real-world problems is incredibly satisfying. 

5. What was it like to collaborate with other professors at the Ritchie School?

Collaboration is crucial to our scientific success. The Ritchie School has created an environment that strongly supports this. 

As part of the Knoebel Institute of Healthy Aging, I have access to excellent lab resources and facilities. It's easy to connect with other professors in the same building and collaborate with students from different labs, whether for collaboration, suggestions, or quick questions. The diverse expertise and perspectives of my colleagues have significantly enhanced our research projects, leading to innovative solutions. This collaborative atmosphere fosters continuous learning and mutual support, allowing ideas to be freely exchanged and refined. Working with such talented and dedicated colleagues has been both inspiring and essential in advancing our collective research goals.

6. What was it like to collaborate with Ritchie School students on the article?

The first author of the paper, my top student Alfred Akinlalu is exceptionally smart, motivated, and diligent. I am very proud that he has won the DU doctoral fellowship. All my students are highly motivated, excellent and come from diverse backgrounds. It is an honor to be their mentor, and I strive to guide them through the learning process.

7. What is something you’d like the Ritchie School community to know about your research?

Cancer patients still endure severe side effects from treatments and face significant economic burdens because many cancer therapies are very costly. Our lab aims to address these issues from an engineering perspective to work on low-cost cancer detection and treatment solution. Don’t rely on the pharmaceutical industry to focus on these lower-profit therapies; we need your support to continue our research. Our lab is deeply committed to advancing research that has a tangible impact on patient care and health outcomes.

“There’s no really good solution for cancer yet. Patients suffer a lot, and then the current treatment may introduce more side effects. We want to find a mastered solution that does not introduce a lot of side effects that will lower the risk (of suffering) for a patient.” 

If you’re interested in exploring more of the research at the Ritchie School,  please check out our page on Research and Innovation . Students can learn from Dr. Dali Sun in courses such as Biosensing Technology (ENGR-3/4450), Instrumentation and Data Acquisition (ENER-3/4100), and Applied MATLAB Programming (ENGR-1572).

Related Articles

Researcher Uses Engineering Methods to Reveal Promising Pancreatic Cancer Treatment

Ritchie School Computer Science Student Ori Miller Utilizing Robotics Research to Make a Difference

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